Nucleic acids encoding a gap-associated protein

Details Nucleic acids encoding a gap-associated protein Nucleic acids encoding a gap-associated protein

1995-05-10

1998-03-24

Houtteman, Scott W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530358, 435 6, C07H 2104

Patent

active

057314276

ABSTRACT:
The subject invention provides for nucleotide sequences encoding polypeptide p62 and derivatives thereof. Another aspect of the subject invention also provides for methods of purifying p62 and derivatives thereof from cells naturally producing p62 and from cells genetically modified so as to produce p62. The subject invention also provides for methods of assaying tyrosine kinase activity by means of measuring the phosphorylation of p62 and p62 derivatives. Measurement of p62/p62 derivative phosphorylation may be used to determine whether or not a call is cancerous.

REFERENCES:
Ellis et al., Nature (Jan. 25, 1990) 343:377-381.
Boguski et al., Nature (Dec. 16, 1993) 366(6456):643-654.

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