Nucleic acids encoding a chimeric glycosyltransferase

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C536S023100, C435S064000, C435S325000

Reexamination Certificate

active

07001998

ABSTRACT:
The invention relates to nucleic acids which encode glycosyltransferase and are useful in producing cells and organs from one species which may be used for transplantation into a recipient of another species. It also relates to the production of nucleic acids which, when present in cells of a transplanted organ, result in reduced levels of antibody recognition of the transplanted organ.

REFERENCES:
patent: WO 94/12646 (1994-06-01), None
patent: WO 94/21799 (1994-09-01), None
patent: WO 95/34202 (1995-12-01), None
Schwientek et al., “Golgi localization and in vivo activity of a mammalian glycosyltransferase (human beta-1,4-galactosyltransferase) in yeast”, J. Biol. Chem., 271(7):3398-3405, Feb. 1996.
Sandrin et al., “Characterization of cDNA clones for porcine alpha(1,3)galactosyltransferase: the enyzme generating the gal-alpha(1,3)gal epitope”, Xenotransplantation, 1:81-88, 1994.
Colley, “Golgi localization of glycosyltransferases: more question than answers”, Glycobiology, 7(1):1-13, Feb. 1997.
Machamer, “Targeting and retention of Golgi membrane proteins”, Curr. Opin. Cell Biol., 5(4):606-612, Sep. 1993.
Gleeson et al., “Targeting of proteins to the Golgi apparatus”, Glycoconj. J., 11:381-394, 1994.
Anderson et al., “Human gene therapy”, Nature, 392(Supp.):25-30, Apr. 1998.
Verma and Somia, “Gene therapy-promises, problems and prospects”, Nature, 389:239-242, Sep. 1997.
Chen, Choa-Guang et al: “Reduction in Gal-alpha- 1, 3-Gal Epitope Expression in Transgenic Mice Expressing Human H- Transferase.” XENOTRANSPLANTATION, (1996) vol. 3, No. 1 Part 2, pp. 69.
Cooper D K C et al: “Oligosaccharides and Discordant Xenotransplantation” Immunological Reviews, XX, Munksgaard, vol. 141, Oct. 1, 1994, pp. 31.
Dahdal R Y et al.: “Specific Sequences In The Signal Anchor Of The Beta-Galactoside Alpha- 2, 6- sialytransferase Are Not Essential For Goldi Localization. Membrane Flanking Sequences May Specify Golgi Retention.” Journal Of Biological Chemistry, (Dec. 15, 1993) pp. 26310.
Gustafsson K et al: “Alpha1, 3Galactosyltransferase: A Target For In Vivo Genetic Manipulation In Xenotransplantation” Immunological Reviews, XX, Munksgaard, vol. 141, No. 1, Jan. 1, 1994, pp. 59.
Sandrin, M. S. et al.: “Transgenic Approaches For The Reduction In Expression of Galalpha (1,3) Gal For Xenotransplantation.” pp. 1.
Sharma A et al.: “Reduction In The Level Of Gal (alpha, 3) Gal in Transgenic Mice and Pigs By The Expression Of An Alpha (1,2) Fucosyltransferase.” Proceedings Of The National Academy Of Sciences Of The United State Of America, Jul. 9, 1996, pp. 7190.
J.R. Leventhal, et al.; “Complement Depletion Prolongs Discordant Cardiac Xenograft Survival in Rodents and Non-Human Primates”;Transplantation Proceedings; 1993; vol. 25, No. 1, pp. 398-399.
Scott K. Pruitt et al.; “The Effect of Soluble Complement Receptor Type 1 on Hyperacute Rejection of Porcine Xenografts”;Transplantation; Feb. 3, 1994; vol. 57, pp. 363-370.
Joseph R. Leventhal et al.; “Removal of Baboon and Human Antiporcine IgG and IgM Natural Antibodies by Immunoadsorption”;Transplantation; Jan. 27, 1995, vol. 59, pp. 294-300.
R.J. Brewer et al.; “Depletion of Preformed Antibody in Primates for Discordant Xenotransplantation by Continuous Donor Organ Plasma Perfusion”;Transplantation Proceedings; 1993; vol. 25, No. 1, pp. 385-386.
Kenneth R. McCurry et al.; “Human Complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury”;Nature Medicine; May 5, 1995; vol. 1, No. 5, pp. 423-427.
William L. Fodor et al.; “Expression of a functional human complement inhibitor in a transgenic pig as a model for the prevention of xenogeneic hyperacute organ rejection”;Proc. Natl. Acad. Sci.; Nov. 1994; vol. 91, pp. 11153-11157.
Ariella M. Rosengard et al.; “Tissue Expression of Human Complement Inhibitor, Decay-Accelerating Factor, in Transgenic Pigs”;Transplantation; May 15, 1995; vol. 59, No. 9, pp. 1325-1333.
Mauro S. Sandrin & Ian F.C. McKenzie; “Galα(1,3)Gal, the Major Xenoantigen(s) Recognised in Pigs by Human Natural Antibodies”;Immunological Reviews; 1994; No. 141, pp. 169-190.
Mauro S. Sandrin et al.; “Characterization of cDNA clones for porcine α(1,3)galactosyl transferase: The enzyme generating the Galα(1,3)Gal epitope”;Xenotransplantation; 1994; pp. 81-88.
David H. Joziasse et al.; “Characterization of an α1→3-Galactosyltransferase Homologue on Human Chromosome 12 That Is Organized as a Processed Pseudogene”;Journal of Biological Chemistry; 1991; vol. 266, No. 11, pp. 6991-6998.
Robert D. Larsen et al.; “Framshift and Nonsense Mutations in a Human Genomic Sequence Homologous to a Murine UDP-Gal:β-D-Gal(1,4)-D-GlcNAc α(1,3)-Galactosyltransferase cDNA”;Journal of Biological Chemistry; 1990; vol. 265, No. 12, pp. 7055-7061.
Mauro S. Sandrin et al.; “Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis”;Nature Medicine; Dec. 1995; vol. 1, No. 12, pp. 1261-1267.
Mauro S. Sandrin, William L. Fodor, Effie Mouhtouris, Narin Osman, Shlomo Cohney, Scott A. Rollins, Edward R. Guilmette, Eva Setter, Stephen P. Squinto & Ian F.C. McKenzie; Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis;Nature Medicine; Dec. 1995; vol. 1, No. 12, pp. 1261-1267.
Jo Burke, John M. Pettitt, Danielle Humphris, and Paul A. Gleeson; “Medial-Golgi Retention on N-Acetylglucosaminyltransferase I”;Journal of Biological Chemistry; Apr. 22, 1994; vol. 269, No. 16, pp. 12049-12059.
Narin Osman, Ian F.C. McKenzie, Effie Mouhtouris, and Mauro S. Sandrin; “Switching Amino-terminal Cytoplasmic Domains of α(1,2) Fucosyltransferase and α(1,3) Galactosyltransferase Alters the Expression of H Substance and Galα(1,3)Gal”;Journal of Biological Chemistry; Dec. 20, 1996; vol. 271, No. 51, pp. 33105-33109.
Mauro S. Sandrin et al.; “Anti-pig IgM antibodies in human serum react predominantly with Gal(α1-3)Gal epitopes”;Proc. Natl. Acad. Sci.; Dec. 1993; vol. 90, pp. 11391-11395.
Mauro S. Sandrin et al.; “Identification of Gal(α1,3)Gal as the Major Epitope for Pig-to-Human Vascularised Xenografts”;Transplantation Reviews; 1994; vol. 8, No. 3, pp. 134-149.
DKC Cooper et al.; “Identification ofα-galactosyl and other carbohydrate epitopes that are bound by human anti-pig antibodies: relevance to discordant xenografting in man”;Transplant Immunology; 1993; pp. 198-205.
David K.C. Cooper et al.; “Oligosaccharides and Discordant Xenotransplantation”;Immunological Reviews; 1994; No. 141, pp. 31-58.
Uri Galili et al.; “Evolutionary relationship between the natural anti-Gal antibody and the Galα1→3Gal epitope in primates”;Proc. Natl. Acad. Sci.; Mar. 1987; vol. 84, pp. 1369-1373.
Uri Galili et al.; “Man, apes, and Old World Monkeys Differ from Other Mammals in the Expression of α-Galactosyl Epitopes on Nucleated Cells”;Journal of Biological Chemistry; 1988; vol. 263, No. 33, pp. 17755-17762.
Robert d. Larsen et al.; “Isolation of a cDNA encoding a muring UDPgalactose:β-D-galactosyl-1,4-N-acetyl-D-glucosaminide α-1,3-galactosyltransferase: Expression cloning by gene transfer”;Proc. Natl. Acad. Sci.; Nov. 1989; vol. 86, pp. 8227-8231.
David H. Joziasse et al.; “Murine α1,3-Galactosyltransferase”;Journal of biological Chemistry, 1992; vol. 267, No. 8, pp. 5534-5541.
David H. Joziasse et al.; “Bovine α1→3-Galactosyltransferase: Isolation and Characterization of

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acids encoding a chimeric glycosyltransferase does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids encoding a chimeric glycosyltransferase, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding a chimeric glycosyltransferase will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3641988

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.