Nucleic acids encoding a cellulose binding domain

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

536 231, 536 2433, 4353201, 4352523, C07H 2104, C12N 1531

Patent

active

054969344

ABSTRACT:
A cellulose binding domain (CBD) having a high affinity for crystalline cellulose and chitin is disclosed, along with methods for the molecular cloning and recombinant production thereof. Fusion products comprising the CBD and a second protein are likewise described. A wide range of applications are contemplated for both the CBD and the fusion products, including drug delivery, affinity separations, and diagnostic techniques.

REFERENCES:
patent: 5137819 (1992-08-01), Kilburn et al.
patent: 5229501 (1993-07-01), Keifer et al.
Bowie et al. 1990. Science 247: 1306-1310.
Watson et al. 1987. Molecular Biology of The Gene, Fourth Ed., p. 313.
Jauris et al. 1990. Mol. Gen. Genet. 223:258-267.
Poole et al. 1992. FEMS Microbiol. Lett. 99:181-6.
Nilsson et al., "Immobilization and purification of enzymes with staphylocal protein A gene fusion vectors," EMBO J. 4(4):1075-1080 (1985).
Mehra et al., "Efficient mapping of protein antigenic determinants," Proc. Natl. Acad. Sci. USA 83: 7013-7017 (1986).
Shinnick, Thomas M., "The 65-Kilodalton Antigen of Mycobacterium tuberculosis," J. of Bacteriology 169(3):1080-1088 (1987).
Cabib, Enrico, "Chitinase from Serratia marcescens," Methods in Enzymology 161:460-462 (1988).
van Enden et al., "Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis," Nature 331:171-173 (1988).
Shinnick et al., "The Mycobacterium tuberculosis 65-Kilodalton Antigen Is a Heat Shock Protein Which Corresponds to Common Antigen and to the Escherichia coli GroEL Protein," Infection and Immunity 56(2):446-451 (1988).
Hemmingsen et al., "Homologous plant and bacterial proteins chaperone oligomeric protein assembly," Nature 333:330-334 (1988).
Greenwood et al., "Fusion to an endoglucanase allows alkaline phosphatase to bind to cellulose," EBS Letters 244(1):127-131 (1989).
Jindal et al., "Primary Structure of a Human Mitochondrial Protein Homologous to the Bacterial and Plant Chaperonins and to the 65-Kilodalton Mycobacterial Antigen," Mol. and Cell. Biol. 9(5):2279-2283 (1989).
Picketts et al., `Molecular Cloning of a Chinese Hamster Mitochondrial Protein Related to the "Chaperonin" Family of Bacterial and Plant Proteins,` J. Biol. Chem. 264: 12001-12008 (1989).
Ellis, John, "The molecular chaperone concept," Seminars in Cell Biology 1:1-9 (1990).
Billingham et al., "A Mycobacterial 65-kD Heat Shock Protein Induces Antigen-Specific Suppression of Adjuvant Arthritis, But Is Not Itself Arthritogenic," J. Exp. Med. 171:339-344 (1990).
Elias et al., "Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein," Proc. Natl. Acad. Sci. USA 87:1576-1580 (1990).
Shoseyov et al., "Essential 170-kDa subunit for degradation of crystalline cellulose by Clostridium cellulovorans cellulase," Proc. Natl. Acad. Sci. USA 87:2192-2195 (1990).
Shoseyov et al., "Immobilized Endo-.beta.-glucosidase Enriches Flavor of Wine and Passion Fruit Juice," JAFCU 38(6):1387-1390 (1990).
Venner et al., "Nucleotide sequence of rat hsp60 (chaperonin, GroEL homolog) cDNA," Nuc. Acids Res. 18(17):5309 (1990).
Klyosov, Anatole A., "Trends in Biochemistry and Enzymology of Cellulose Degradation," Biochemistry 29(47):10577-10585 (1990).
van Eden, Willem, "Heat-Shock Proteins as Immunogenic Bacterial Antigens with the Potential to Induce and Regulate Autoimmune Arthritis," Immunological Reviews 121:5-28 (1991).
Shoseyov et al., "Primary sequence analysis of Clostridium cellulovorans cellulose binding protein A," Proc. Natl. Acad. Sci. USA 89:3483-3487 (1992).
Hermann et al., "Synovial fluid-derived Yersinia-reactive T cells responding to human 65-kDa heat-shock protein and heat-stressed antigen-presenting cells," Eur. J. Immunol. 21:2139-2143 (1991).
Din et al., "Non-Hydrolytic Disruption of Cellulose Fibres by the Binding Domain of a Bacterial Cellulase," Bio/Technology 9:1096-1099 (1991).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acids encoding a cellulose binding domain does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids encoding a cellulose binding domain, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids encoding a cellulose binding domain will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1414130

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.