Nucleic acids db, the receptor for leptin

Details Nucleic acids db, the receptor for leptin Nucleic acids db, the receptor for leptin

2006-06-20

2006-06-20

O'Hara, Eileen B. (Department: 1646)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S320100, C435S252310, C435S252330, C435S252340, C435S252350, C435S254210, C435S254220, C435S255600, C435S255400, C435S358000, C435S365000, C435S348000, C435S354000, C435S357000, C536S023500, C530S350000

Reexamination Certificate

active

07063958

ABSTRACT:
The present invention relates to identification of a receptor for a satiety factor, which is involved in body weight homeostasis. Mutations in this receptor are associated with obese phenotypes. In particular, the present invention relates to identification and characterization of the receptor for leptin, including a naturally occurring soluble form of the receptor that is expected to modulate leptin activity, in particular to agonize leptin activity. The invention further relates to the nucleic acids encoding the receptor, and to methods for using the receptor, e.g., to identify leptin analogs, therapeutically, such as in gene therapy or in soluble form as an agonist or antagonist of leptin activity, or diagnostically.

REFERENCES:
patent: 5194596 (1993-03-01), Tischer et al.
patent: 5350836 (1994-09-01), Kopchick et al.
patent: 5359046 (1994-10-01), Capon et al.
patent: 5643748 (1997-07-01), Snodgrass et al.
patent: 6506877 (2003-01-01), Tartaglia et al.
patent: 90/14092 (1990-11-01), None
patent: 91/06666 (1991-05-01), None
patent: 91/09955 (1991-07-01), None
patent: 9712037 (1996-09-01), None
patent: 9635787 (1996-11-01), None
patent: 9725424 (1997-01-01), None
patent: 9731015 (1997-02-01), None
patent: 9712037 (1997-04-01), None
patent: 9740380 (1997-04-01), None
patent: 9741217 (1997-04-01), None
patent: 9741263 (1997-04-01), None
patent: 9742340 (1997-05-01), None
patent: 9719952 (1997-06-01), None
patent: 9725425 (1997-07-01), None
patent: 9726523 (1997-07-01), None
Cioffi et al,Nature Medicine2(5) 1996, 585-89.
Bennett et al,Current Biology6(9) 1996, p. 1170-80.
Chen et alCell84 Feb. 1996, p. 491-95.
Chua et al,Science271, Feb. 1996, p. 994-96.
Tartaglia et alCell83, Dec. 1995, p. 1268-71.
Vukicevic et al., 1996, PNAS USA 93:9021-9026.
Wang et al. (Nuc. Acids Res. 27: 4609-4618, 1999; p. 4617).
Kaufman et al (Blood 94: 3178-3184, 1999, pp. 3178-3184).
Wigley et al. Reprod Fert Dev 6: 585-588, 1994.
Campbell et al. Theriology 47(1): 63-72, 1997.
Phillips, A., J Pharm Pharmacology 53: 1169-1174, 2001.
Bahary et al. (1990) Proc. Natl. Acad. Sci. USA 87:8642-6.
Bahary et al.,Mammalian Genome, 4:511-515 (1993).
Bennett et al., Current Biology, 6(9): 1170-80, (1996).
Bray et al.,Am. J. Clin. Nutr., 50:891-902 (1989).
Burkhardt et al. (1994)Mol. Cell. Biol., 14:1095.
Campfield et al.,Science, 269:546 (1995).
Chen et al., Cell, 84: 491-95, (1996).
Chua et al., Science, 271: 994-6 (1996).
Church et al,Nature Genetics, 6:98 (1994).
Coleman,Diabetologia, 9:294-298 (1973).
Coleman et al.,Diabetologia, 14:141-148 (1978).
Considine et al.,J. Clin. Invest., 95:2986 (1995).
Dalton et al. (1993) Science 259:1736-9.
Davis et al. (1993) Science 260:1805-7.
Friedman et al.,Genomics, 11:1054-1062 (1991).
Fukunaga, et al.,EMBO, 10:2855 (1991).
Halaas et al.,Science, 269:543 (1995).
Hamilton et al.,Nature Med., 1:953 (1995).
Kishimoto et al. (1994) Cell 76:253-62.
Leiter,Endocrinology, 124:912-922 (1989).
Lonnqvist et al.,Nature Med., 1:950 (1995).
Maffei et al.,Nature Med., 1:1155 (1995).
Milatovich et al.,Somatic Cell Mol. Gen., 20:75 (1994).
Modl et al.,Cytogenetics Cell Genetics, 67:232 (1995).
Moll et al.,Am. J. Hum. Genet., 49:1243-1255 (1991).
Morgan et al.,Nucl. Acids Res., 20:5173 (1992).
Murakami et al.,Proc. Natl. Acad. Sci. USA, 88:11349 (1991).
Pellymounter et al.,Science, 269:540, (1995).
Riley et al.,Nucl. Acids Res., 18:2887 (1990).
Sanchez et al.,J. Exp. Med., 178:1049 (1993).
Stephens et al.,Nature, 377:530 (1995).
Tartaglia et al. (1995) Cell 83:1263-71.
Truett et al.,Proc. Natl. Acad. Sci. USA, 88:7806-7809 (1991).
Turton et al.,Nature, 379:69 (1996).
Zhang et al.,Nature, 372:425 (1994).

Affiliated with

Also associated with

Rating

Nucleic acids db, the receptor for leptin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids db, the receptor for leptin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids db, the receptor for leptin will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3662176