Nucleic acids, compositions and methods for the excision of...

Details Nucleic acids, compositions and methods for the excision of... Nucleic acids, compositions and methods for the excision of...

2011-04-05

2011-04-05

Joike, Michele K (Department: 1636)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S254200, C435S471000

Reexamination Certificate

active

07919605

ABSTRACT:
Nucleic acids, compositions, and methods that allow for the excision of one or more loci from the genome of a host cell are provided herein. In particular, provided herein is an excisable nucleic acid construct comprising, in a 5′ to 3′ orientation: a first tandem repeat nucleic acid, a first homing endonuclease recognition site, a target nucleic acid, a second homing endonuclease recognition site, and a second tandem repeat nucleic acid. In some embodiments, the excisable nucleic acid construct is integrated into the host cell genome, and the target nucleic acid can be excised from the host cell genome by contacting the homing endonuclease recognition sites with one or more appropriate homing endonucleases.

REFERENCES:
patent: 2005/0172365 (2005-08-01), Puchta et al.
Zeng, et al.,Current Biology, (2009), 19:218-222.

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