Nucleic acids coding for adhesion factor of group B...

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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Details

C536S022100, C435S007100, C435S007320, C435S007340, C424S278100, C530S350000

Reexamination Certificate

active

07485710

ABSTRACT:
The present invention is related to nucleic acids coding for adhesion factors of group Bstreptococcus, adhesion factors of group Bstreptococcusand uses thereof. More particularly, the present invention is related to a polypeptide being such adhesion factors and comprising an amino acid sequence, whereby the amino acid sequence is selected from the group comprising SEQ ID NO 11 to SEQ ID NO 20, and the use of such polypeptide for the manufacture of a vaccine.

REFERENCES:
patent: WO 00/06736 (2000-02-01), None
patent: WO 02092818 (2002-11-01), None
Glaser et al.: “Genome sequence ofStreptococcus agalactiae, a pathogen causing invasive neonatal disease,” Molecular Microbiology, vol. 45, No. 6, Sep. 27, 2002, p. 1499-1513.
Tettelin Herve et al: “Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype VStreptococcus agalactiae,” Proceedings of the National Academy of Sciences of the United States, vol. 99, No. 19, Sep. 17, 2002, pp. 12391-12396.
Meehan M. et al: “Affinity Purification and Characterization of a Fibrinogen-Binding Protein Complex Which Protects Mice Against Lethal Challenge WithStreptococcus EquiSubsp. Equi,” Microbiology, Society for General Microbiology, Reading, GB, vol. 144, No. 4, 1998, pp. 993-1003-1130.
Schubert Axel et al: “A fibrinogen receptor from group BStreptococcusinteracts with fibrinogen by repetitive units with novel ligand binding sites,” Molecular Microbiology, vol. 46, No. 2, Oct. 24, 2002, pp. 557-569.
Database EMBL ′Online! Glaser et al.: “Streptococcus agalactiaegenome sequence, use for developing vaccines, diagnostic tools and for identifying therapeutic targets,” retrieved from EMBL Database accession No. AX602133.
Database EMBL ′Online!, Jul. 1, 2002, Telford et al.: “Nucleic acids and proteins fromStreptococcusgroups a & b,” Database accession No. CQ655069.
Osaki M. et al.: “Characterization ofStreptococcusSuis Genes Encoding Proteins Homologous to Sortase of Gram-Positive Bacteria,” Journal of Bacteriology, Washington, DC, US, vol. 184, No. 4, Feb. 2002, pp. 971-982.
Jacobsson Karin: “A novel family of fibrinogen-binding proteins inStreptococcus agalactiae,” Veterinary Microbiology, vol. 96, No. 1, Oct. 8, 2003, pp. 103-113.

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