Nucleic acids and vector encoding HMFQ polypeptide, transfected

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 697, 4352523, 4353201, 536 234, 536 235, C12P 2102, C12N 1512

Patent

active

055366473

ABSTRACT:
A polypeptide has the antibody binding activity of the 70K dalton HMFG differentiation antigen and is also provided as a fusion protein with a second antigenic polypeptide. An antibody has affinity for the polypeptide of the invention or a functional fragment thereof. in vivo and in vitro methods for therapy, vaccination and detecting the presence of the polypeptide, the antibody, the DNA and RNA of the invention are provided. DNA and RNA sequences encode the polypeptide of the invention or fragments thereof and immunoassay kits comprise the antibodies and/or polypeptides of the invention.

REFERENCES:
Larocca, D., et al, (1990) Cancer Res, 50, 5925, 5930.
Larocca et al. (1990) Cancer Research, vol. 50, "Cloning and Sequencing of a Complementary DNA Encoding a Mr 70,000 human breast epithelial mucin-associated Antigen," pp. 5925-5930.
Young et al. (1983) Proc. Natl. Acad. Sci., vol. 80, "Efficient Isolation of Genes by Using Antibody Probes", pp. 1194-1198.
J. Sambrook, E. F. Fitsch, and T. Maniatis, "Molecular Cloning a Laboratory Manual, " 2nd ed., Cold Spring Harbor, NY, 1989.
Imam, A. et al. (1984) Cancer Research "Immunohistochemical Study of the Expression of Human Milk Fat Globule Membrane Glyco-protein 70." vol. 44 pp. 2016-2022.
Barrett, J. T. (1983) Textbook of Immunology, C. V. Mosby Co., St. Louis pp. 250-252.
Ceriani et al. (1983) Somatic Cell Genetics vol. 9, No. 4 415-427.
Imam et al. (1981) Biochemical Journal vol. 193, 47-54.
Ceriani et al. (1986) Mechanisms of Cancer Metastasis Horm, Powers, Sloane (eds) pp. 237-257.
Ceriani et al, Potential Therapeutic Implications 235-258 (1986).
Ceriani et al, Immunochemistry in Tumor Diagnosis: 233-263 (1985).
Ceriani et al, Cancer Research 47:532-540 (1987).
Ceriani et al, Cancer Research 48:4664-4672 (1988).
Ceriani et al, Somatic Cell Genetics 9:415-427 (1983).
Ceriani et al, PNAS (USA) 74:582-586 (1987).
Peterson et al, Hybridomma (in press, 1990).
Gendler et al, PNAS (USA) 85:2320-2323 (1988).
Gendler et al, Biological Chemistry 263:12820-12823 (1988).
Siddiqui et al, PNAS (USA) 85:2320-2323 (1988).
Taylor-Papadimitriou et al, Breast Cancer Immunodiagnosis and Immunotherapy, Plenum Publishing Corp., New York, 81 (1990).
Xing et al, Breast Cancer Immunodiagnosis and Immunotherapy, Plenum Publ. Corp., N.Y., 211 (1990).
Abe et al, Cancer Research 49:2834-2839 (1989).
Ceriani et al, PNAS (USA) 79:5420-5424 (1982).
Duwe et al, BBRC 165:1305-1311 (1990).
Imam et al, Biochemistry Journal 193:47-54 (1981).
Imam et al, British Journal of Cancer 3:373-378 (1988).
Heid et al, BBA 2:228-238 (1983).
Imam, et al, British Journal of Cancer 3:373-378 (1988).
Peterhans, et al, Analytical Biochemistry 163:470-475 (1987).
Imam, et al, Biochemical Journal 193:47-54 (1981).
Ceriani, et al, Chapter 16 "Breast Cancer Diagnosis with Human Mammary Epithelial Antigens and the Prospective use of Antibodies Them in Therapy", in Mechanisms of Cancer Metastasis: Potential Therapeutic Implications, pp. 235-257 (1986).
Peterson, Jerry A. et al. "Biochemical and Histological Characterization of Antigens Preferentially expresses on the surface and Cytoplasm of Breast Carcinoma Cells Identified by Monoclonal Antibodies against the Human Milk Fat Globule" Hybridoma. vol. 9 No. 3 (1990).
Xing et al, "Reaction of Antibodies to Human Milk Fat Globule (HMFG) With Synthetic Peptides", Breast Cancer Immunodiagnosis & Immunotherapy (Plenum Press) 1990.
Miyako Abe et al, "Structural Analysis of the DF3 Human Breast Carcinoma-associated Protein", Cancer Research 49, 2834-2839 (1989).
Ceriani et al, "Circulating Human Mammary Epithelial Antigens in Breast Cancer", Proc. Natl. Acad. Sci. pp. 5420-5424 (1982).
Duwe et al, "Human Milk-Fat Globule Membrane Derived Mucin is a Disulfide-Linked Heteromer", Biochemical & Biophysical etc. pp. 1305-1311 (1989).
Imam et al, "Isolation and Characterization of a Major Glycoprotein from Milk-Fat Globule Membrane of Human Breast Milk", Human Cancer Biology, vol. 193, pp. 47-54 (1981).
Heid et al, "Butyrophilin, An Apical Plasma Membrane-Associated Glycoprotein Characteristic of Lactating Mammary Glands of Diverse Species", Elsevier Biomedical Press, pp. 228-238 (1982).
Peterhans, A., Mecklenburg, M., Meussdoerffer, F., and Mosbach, K. "A Simple Competitive Enzyme-Linked Immunosorbent Assay Using Antigen-.beta.-Galactosidase Fusions", Analytical Biochemistry 163:470-475, (1987).
Imam, A., Yoshida, S. O., and Taylor, C. R. "Distinguishing Tumor Cells of Mammary From Extramammary Paget's Disease Using Antibodies to Two Different Glycoproteins From Human Milk-Fat-Globule Membrane", British Journal of Cancer, 58:373-378 (1988).
Imam, A., Laurence, D. J. R. and Neville, A. M. "Isolation And Characterization of A Major Glycoprotein From Milk-Fat-Globule Membrane of Human Breast Milk", Biochemistry Journal 193:47-54 (1981).
Ceriani, R. L., Peterson, J. A. and Blank, E. W. "Chapter 16: Breast Cancer Diagnosis With Human Mammary Epithelial Antigens And The Prospective Use of Antibodies Against Them In Therapy" Mechanism of Cancer Metastasis: Potential Therapeutic Implications. Honn, Powers, Sloane (editors) pp. 235-257 (1986).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acids and vector encoding HMFQ polypeptide, transfected does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acids and vector encoding HMFQ polypeptide, transfected , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acids and vector encoding HMFQ polypeptide, transfected will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1783819

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.