Nucleic acids and proteins of insect Or83b odorant receptor...

Details Nucleic acids and proteins of insect Or83b odorant receptor... Nucleic acids and proteins of insect Or83b odorant receptor...

2007-05-09

2009-06-23

Ulm, John D (Department: 1649)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S069100, C435S252300, C435S320100

Reexamination Certificate

active

07550574

ABSTRACT:
The present invention relates to insect odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of insect odorant receptor genes Or83b, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may be operatively linked to promoter sequences and transformed into host cells. Methods of production of an Or83b odorant receptor protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Antibodies to an Or83b odorant receptor protein, and derivatives and analogs thereof, are provided. Methods for identifying molecules that bind or modulate the activity of these Or83b odorant receptor genes are provided. Molecules found to bind or modulate the activity of Or83b genes may be formulated into pest control agents by providing a carrier. In a preferred embodiment, molecules that bind or modulate the activity of an Or83b gene from one species but not others is desired. Methods to modify the insect behavior by modifying an insect Or83b odorant are also provided.

REFERENCES:
patent: 6703491 (2004-03-01), Homburger et al.
patent: WO-00/50566 (2000-08-01), None
Vosshall et al. A Spacial Map of Olfactory Receptor Expression in theDrosophilaAntenna, Mar. 5, 1999, Cell 96:725-736.
Jones et al. Functional Conservation of an Insect Odorant Receptor Gene Across 250 Million Years of Evolution. Feb. 22, 2005, Current Biology 15(4):R119-R121.
Pitts et al. A Highly Conserved Candidate Chemoreceptor Expressed in Both Olfactory and Gustatory Tissues in the Malaria Vector Anopheles gambiae, Apr. 6, 2004, P.N.A.S. 101(14):5058-5063.
L. B. Vosshall et al., “An olfactory sensory map in the fly brain,” Cell, vol. 102, No. 2, 147-159 (Jul. 21, 2000).

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