Nucleic acids and polypeptides which resemble Rho and which...

Details Nucleic acids and polypeptides which resemble Rho and which... Nucleic acids and polypeptides which resemble Rho and which...

2002-12-27

2008-10-28

Slobodyansky, Elizabeth (Department: 1652)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C530S350000

Reexamination Certificate

active

07442534

ABSTRACT:
The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, including, e.g., a PAK regulatory domain binding activity, a PAK kinase stimulatory activity, a JNK kinase stimulatory activity, a cytoskeletal-reorganizing activity, or a Chp-specific immunogenic activity. The invention relates to all aspects of Chp, or homologs thereof, including assays for modulators, activators, ligands, etc.

REFERENCES:
patent: 6500653 (2002-12-01), Abo et al.
patent: WO 96 20948 (1996-07-01), None
SIGMA Catalog (1997, p. 1159, product G5149).
Mary Ann Sells and Jonathan Chernoff, “Emerging from the Pak: the p21-activated protein kinase family,” Trends in Cell Biology, vol. 7, Issue 4, Apr. 1997, pp. 162-167.
Martin, A.G., et al., “A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20,” EMBO, vol. 14, No. 9, 1995, pp. 1970-1978.
Aronheim et al. “Chp, a homologue of the GTPase Cdc42Hs, activates the JNK . . . ” Current Biology (1998), vol. 8, No. 20, pp. 1125-1128.
Nucleotide Sequence Database EMBL, ID: HSZZ3005; Acc. No. AA367838, Apr. 1997, Adams et al.
Bagrodia et al. “Cdc42 and PAK-mediated Signaling Leads to Jun Kinase and p38 Mitogen-activiated Protein Kinase Activation” (1995), Jnl. Biol. Chem. vol. 270, No. 47, pp. 27995-27998.
Nobes et al. “Rho, Rac, and Cdc42 GTPases Regulate the Assembly . . . ” (1995) Cell, vol. 81, pp. 53-62.
Aromheim et al. (Jun. 1997) Molecular and Cellular Biology, vol. 17. pp. 3094-3102.
NCBI Genbank Accession No. AAL17966, Rho family GTPase Chp [Homo sapiens], Feb. 13, 2002.
NCBI Genbank Accession No. AAH86990, Ras homolog gene family, member V [Rattus norvegicus], Jul. 25, 2005.
Erickson, J.W., et al., “Mammalian Cdc42 is a brefeldin A-sensitive component of the Golgi apparatus,” J Biol Chem. Oct. 25, 1996;271(43):26850-4.

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