Nucleic acids and polypeptides involved in the production of...

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Oxidoreductase

Reexamination Certificate

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C435S183000, C435S069100, C435S320100, C435S252300, C435S252100, C536S023200, C536S023100

Reexamination Certificate

active

07662599

ABSTRACT:
The present invention provides polypeptides involved in cryptophycin biosynthesis and the nucleic acid molecules that encode such polypeptides. The nucleic acid molecules and polypeptides of the invention or variants thereof can be used in the methods of the invention to produce cryptophycins.

REFERENCES:
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4800159 (1989-01-01), Mullis et al.
patent: 4845085 (1989-07-01), Sesin
patent: 4845086 (1989-07-01), Sesin
patent: 4874748 (1989-10-01), Katz et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 5063155 (1991-11-01), Cox et al.
patent: 5098837 (1992-03-01), Beckmann et al.
patent: 5149639 (1992-09-01), Katz et al.
patent: 5672491 (1997-09-01), Khosla et al.
patent: 5712146 (1998-01-01), Khosla et al.
patent: 5830750 (1998-11-01), Khosla et al.
patent: 5843718 (1998-12-01), Khosla et al.
patent: 5945315 (1999-08-01), Moore et al.
patent: 5952298 (1999-09-01), Moore et al.
patent: 5962290 (1999-10-01), Khosla et al.
patent: 6013626 (2000-01-01), Moore et al.
patent: 6022731 (2000-02-01), Khosla et al.
patent: 6090601 (2000-07-01), Gustafsson et al.
patent: 6399789 (2002-06-01), Santi et al.
patent: 6492562 (2002-12-01), Ashley et al.
patent: 6524841 (2003-02-01), McDaniel et al.
patent: 6589968 (2003-07-01), Arslanian et al.
patent: 6660862 (2003-12-01), Reeves et al.
patent: 2002/0065261 (2002-05-01), Corbett et al.
patent: 2003/0219872 (2003-11-01), Hucul et al.
patent: WO 93/13663 (1993-07-01), None
patent: WO 95/08548 (1995-03-01), None
patent: WO 96/40968 (1996-12-01), None
patent: WO 97/02358 (1997-01-01), None
patent: WO 97/07798 (1997-03-01), None
patent: WO 98/27203 (1998-06-01), None
patent: WO 98/38164 (1998-09-01), None
patent: WO 98/49315 (1998-11-01), None
Whisstock et al., Prediction of protein function from protein sequence. Q. Rev. Biophysics., 2003, vol. 36 (3): 307-340.
Witkowski et al., Conversion of b-ketoacyl synthase to a malonyl decarboxylase by replacemnt of the active-site cysteine with glutamine. Biochemistry, 1999, vol. 38: 11643-11650.
Broun et al., Catalytic plasticity of fatty acid modification enzymes underlying chemical diversity of plant lipids. Science, 1998, vol. 282: 1315-1317.
Al-awar et al., “A Convergent Approach to Crytophycin 52 Analogues: Synthesis and Biological Evaluation of a Novel Series of Fragment A Epoxides and Chlorohydrins,”J. Med. Chem., 2003, 46(14):2985-3007.
Barrow et al., “Total Synthesis of Cryptophycins. Revision of the Structures of Cryptophycins A and C,”J. Am. Chem. Soc., 1995, 117(9):2479-2490.
Becker et al., “Cloning, sequencing, and biochemical characterization of the nostocyclopeptide biosynthetic gene cluster: molecular basis for imine macrocyclization,”Gene, 2004, 325:35-42.
Dittmann et al., “Molecular biology of peptide and polyketide biosynthesis in cyanobacteria,”Appl. Microbiol. Biotechnol., 2001, 57(4):467-473.
Eggen and Georg, “The Cryptophycins: Their Synthesis and Anticancer Activity,”Med. Res. Rev., 2002, 22(2):85-101.
Hevel et al., “Unraveling Cryptophycin Biosynthesis,”FASEB J., 1999, 13(7):A1349, Abstract No. 105.
Magarvey et al., “Biosynthetic Characterization and Chemoenzymatic Assembly of the Cryptophycins. Potent Anticancer Agents fromNostocCyanobionts,”ACS Chem. Biol., 2006, 1(12):766-779.
Salamonczyk et al., “Total Synthesis of Cryptophycins Via A Chemoenzymatic Approach,”J. Org. Chem., 1996, 61(20):6893-6900.
Shih and Teicher, “Cryptophycins: A Novel Class of Potent Antimitotic Antitumor Depsipeptides,”Curr. Pharm. Des., 2001, 7(13):1259-1276.
Supplementary European Search Report in EP 05 77 9689 mailed Feb. 20, 2008, 5 pages.
“NiceZyme View of Enzyme: EC 1.3.99.15,” [online]. [retrieved on Mar. 20, 2004]. Retrieved from the Internet: <URL: www.expasy.org/cgi-bin
icezyme.pl?1.3.99.15>, 2 pages.
Boddy et al., “Epothilone C Macrolactonization and Hydrolysis Are Catalyzed by the Isolated Thioesterase Domain of Epothilone Polyketide Synthase,”J. Am. Chem. Soc., 2003, 125:3428-3429.
Challis et al., “Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains,”Chem. Biol., 2000, 7:211-224.
Chiu et al., “Molecular cloning and sequence analysis of the complestatin biosynthetic gene cluster,”Proc. Natl. Acad. Sci. USA, 2001, 98(15):8548-8553.
Dayhoff et al., “A Model of Evolutionary Change in Proteins,”Atlas of Protein Sequence and Structure, 1978, 5(Suppl. 3):345-352.
Eaton, “Organization and Evolution of Naphthalene Catabolic Pathways: Sequence of the DNA Encoding 2-Hydroxychromene-2-Carboxylate Isomerase andtrans-o-Hydroxybenzylidenepyruvate Hydratase-Aldolase from the NAH7 Plasmid,”J. Bacteriol., 1994, 176(24):7757-7762.
Fu et al., “Engineered Biosynthesis of Novel Polyketides: Stereochemical Course of Two Reactions Catalyzed by a Polyketide Synthase,”Biochemistry, 1994, 33:9321-9326.
Eggen et al., “Total Synthesis of Cryptophycin-24 (Arenastatin A) Amenable to Structural Modifications in the C16 Side Chain,”J. Org. Chem., 2000, 65:7792-7799.
Golakoti et al., “Structure Determination, Conformational Analysis, Chemical Stability Studies, and Antitumor Evaluation of the Cryptophycins. Isolation of 18 New Analogs fromNostocsp. Strain GSV 224,”J. Am. Chem. Soc., 1995, 117:12030-12049.
Hans et al., “2-Hydroxyglutaryl-CoA dehydratase fromClostridium symbiosum,” Eur. J. Biochem., 1999, 265:404-414.
Ishikawa and Hotta, “FramePlot: a new implementation of the Frame analysis for predicting protein-coding regions in bacterial DNA with a high G+C content,”FEMS Microbiol. Lett., 1999, 174:251-253.
Jacobsen et al., “SPINDLY, a tetratricopeptide repeat protein involved in gibberellin signal transduction inArabidopsis,” Proc. Natl. Acad. Sci. USA, 1996, 9292-9296.
Kim et al., “Evidence for the role of 2-hydroxychromene-2-carboxylate isomerase in the degradation of anthracene bySphingomonas yanoikuyaeB1,”FEMS Microbiol. Lett., 1997, 153:479-484.
Kinzie et al., “Posttranslational Hydroxylation of Human Phenylalanine Hydroxylase Is a Novel Example of Enzyme Self-Repair within the Second Coordination Sphere of Catalytic Iron,”J. Am. Chem. Soc., 2003, 125:4710-4711.
Kneller et al., “Improvements in Protein Secondary Structure Prediction by An Enhanced Neural Network,”J. Mol. Biol., 1990, 214:171-182.
Kohli et al., “Chemoenzymatic Route to Macrocyclic Hybrid Peptide/Polyketide-like Molecules,”J. Am. Chem. Soc., 2003, 125:7160-7161.
Kohli et al., “Biomimetic synthesis and optimization of cyclic peptide antibiotics,”Nature, 2002, 418:658-661.
Lamb et al., “Tetratrico peptide repeat interactions: to TPR or not to TPR?”Trends Biosci., 1995, 20:257-259.
Landegren et al., “A Ligase-Mediated Gene Detection Technique,”Science, 1988, 241:1077-1080.
Leahy et al., “A Method for Attachment of Peptides to a Solid Surface with Enhanced Immunoreactivity,”BioTechniques, 1992, 13(5):738-743.
Littlechild, “Haloperoxidases and their role in biotransformation reactions,”Curr. Opin. Chem. Biol., 1999, 3:28-34.
Marahiel et al., “Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis,”Chem. Rev., 1997, 97:2651-2673.
Martinez et al., “A Structural Approach into Human Tryptophan Hydroxylase and its Implications for the Regulation of Serotonin Biosynthesis,”Curr. Med. Chem., 2001, 8:1077-1091.
McDaniel et al., “Engineered Biosynthesis of Novel Polyketides,”Science, 1993, 262:1546-1550.
Nakazawa et al., “UV and skin cancer: Specific p53 gene mutation in normal skin as a biologically relevant exposure measurement,”Proc. Natl. Acad. Sci. USA, 1994, 91:360-364.
Neilan et al., “Nonribosomal Peptide S

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