Nucleic acids and expression vectors encoding human leukotiene C

Details Nucleic acids and expression vectors encoding human leukotiene C Nucleic acids and expression vectors encoding human leukotiene C

1994-06-03

1999-09-14

Hendricks, Keith D.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435325, 4353201, 4352542, 4352523, 536 232, 536 2431, 536 2433, C12N 910, C12N 1554

Patent

active

059522100

ABSTRACT:
DNAs which encode human LTC.sub.4 synthase and expression vectors comprising such DNAs are provided. DNAs encoding human LTC.sub.4 synthase may be used in assay methods of the invention for detecting LTC.sub.4 synthase inhibitors. Nucleic acid probes capable of identifying cDNAs and/or genomic DNAs encoding LTC4 synthase, as well as LTC.sub.4 antisense oligonucleotides and analogs which may be administered to viable cells to inhibit production of LTC.sub.4 synthase are also provided.

REFERENCES:
patent: 5244805 (1993-09-01), Miller
Knoth, et al. Nucleic Acids Research, 16, (1988), "Highly degenerate, inosine-containing primers specifically amplify rear cDNA using the polymerase chain reaction".
McPherson, et al. M. J. McPherson, et al., "PCR with highly degenerate primers", in PCR--A Practical Approach, Chapter 11, Oxford University Press, 1991.
Nicholson, et al. Proc. Natl. Acad. Sci. USA, 90:2015-2019 (1993) "Purification to homogeneity and the N-terminal sequence of human leukotriene C.sub.4 synthase: A homodimeric glutathione S-transferase composed of 18-kDa subunits".
Lathe, et al., J. Mol. Biol., (1985), 183:1-12.
Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, 1989, Chapter 11.

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