Nucleic acids and expression systems encoding tyrosylprotein sul

Details Nucleic acids and expression systems encoding tyrosylprotein sul Nucleic acids and expression systems encoding tyrosylprotein sul

1998-09-09

2000-05-09

Wax, Robert A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435325, 4353201, 536 232, C12N 910, C07H 2104

Patent

active

060602953

ABSTRACT:
Tyrosylprotein sulfotransferases and nucleic acids encoding the tyrosylprotein sulfotransferases are described. Dual isotopes of the enzyme and of the nucleic acids encoding said enzymes have been identified in human, mouse and C. elegans. The polypeptides and polynucleotides exhibit a wide range of homologies. The polynucleotides can be used to transform or transfect host cells for producing substantially pure forms of the enzyme, or for use in an expression system for post-translational tyrosine sulfation of proteins or peptides produced within the expression system.

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