Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1995-06-03
1999-11-30
LaGuyader, John L.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4352351, 435325, 530350, 536 231, C12N 1563, C12N 700, C07K 400, C07H 2100
Patent
active
059941090
ABSTRACT:
Nucleic acid transporter systems for delivery of nucleic acid to a cell. The nucleic acid transporter includes a binding complex. The binding complex contains a binding molecule which non-covalently binds to the nucleic acid and covalently links to a surface ligand, nuclear ligand and/or a lysis agent. These may be linked to the binding molecule by spacers.
REFERENCES:
patent: 4490529 (1984-12-01), Rosowsky
patent: 4801575 (1989-01-01), Pardridge
patent: 4891219 (1990-01-01), Karr et al.
patent: 5108921 (1992-04-01), Low et al.
patent: 5166320 (1992-11-01), Wu et al.
patent: 5547932 (1996-08-01), Curiel et al.
Wagner et al. Transferrin-polycation cinjugates as carriers for DNA uptake into cells. Proc. Natl. Acad. Sci. U.S.A. vol. 87, 3410 3414, 1990.
Orkin et al. Report and recommendations of the panel to assess the NIH investment in research on gene therapy, 1995.
Paralkar et al. Identification and characterization of cellular binding proteins (receptors) for recombinant heman bone mmorphogenetic protein 2B, an initiator of bone differentiation cascade Proc. Natl. Acad. Sci. USA vol. 88 3397-3401, 1991.
Abiko, "Syntheses and Structure-Activity Relationships of Thymopoietin," 153-155.
Anderson, "Prospects for Human Gene Therapy," 226 Science 401, 1984.
Audhya et al., "Isolation and Complete Amino Acid Sequence of Human Thymopoietin and Splenin," 84 Proc. Natl. Acad. Sci. USA 3545, 1987.
Baeza et al., "Electron Microscopy and Biochemical Properties of Polyamine-Compacted DNA," 26 Biochemistry 6387, 1987.
Bayne et al., "The C Region of Human Insulin-like Growth Factor (IGF) I is Required for High Affinity Binding to the Type 1 IGF Receptor," 264 J. Biol. Chem. 11004, 1988.
Behr et al., "Efficient Gene Transfer into Mammalian Primary Endocrine Cells with Lipopolyamine-coated DNA," 86 Proc. Natl. Acad. Sci. USA 6982, 1989.
Berstein et al., "A Deeply Recessed Active Site in Angiotensin-Converting Enzyme is Indicated from the Binding Characteristics of Biotin-Spacer-Inhibitor Reagents," 167 Biochem. Biophys. Res. Comm. 310, 1990.
Beukers et al., "[Leu.sup.27 ] Insulin-Like Growth Factor II is Highly Selective for the Type-II IGF Receptor in Binding, Cross-Linking and Thymidine Incorporation Experiments," 128 Endocrinology 1201, 1991.
Bielecki et al., "Bacillus Subtilis Expressing a Haemolysin Gene from Listeria Monocytogenes Can Grow in Mammalian Cells," 345 Nature 175, 1990.
Braulin et al., "Equilibrium Dialysis Studies of Polyamine Binding to DNA," 21(7) Biopolymers 1301, 1982.
Campbell et al., "Folate-Binding Protein Is a Marker for Ovarian Cancer" 51 Cancer Res. 5329, 1991.
Carlsson et al., "Protein Thiolation and Reversible Protein--Protein Conjugation," 173 Biochem. J. 723, 1978 (Printed in Great Britain).
Carswell et al., "Simian Virus 40 Agnoprotein Facilitates Perinuclear-Nuclear Localization of VP1, the Major Capsid Protein," 60(3) J. Virology 1055, 1986.
Cascieri et al., "Structural Analogs of Human Insulin-like Growth Factor (IGF) I with Altered Affinity for Type 2 IGF Receptors," 264 J. Biol. Chem. 2199, 1989.
Cascieri et al., "Characterization of the Biological Activity of IGF I Analogs with Reduced Affinity for IGF Receptors and Binding Proteins," 293 Adv. Exp. Med. Biol. 23, 1991.
Chantry et al., "Cross-reactivity of Amylin with Calcitonin-Gene-Related Peptide Minding Sites in Rat Liver and Skeletal Muscle Membranes," 277 Biochem. J. 139, 1991 (Printed in Great Britain).
Chiba et al., "Calcitonin Gene-Related Peptide Receptor Antagonist Human CGRP -- (8-37)," American Physiological Society, (0193-1849/89), pp. E331-E335 (1989).
Coney et al., "Cloning of a Tumor-Associated Antigen: MOv18 and MOv19 Antibodies Recognize a Folate-Binding Protein," 51 Cancer Res. 6125, 1991.
Cossart and Mengaud, "Listeria Monocytogenes: A Model System for the Molecular Study in Intracellular Parasitism," 6 Mol. Biol. Med. 463, 1989.
Cotten et al., "Transferrin-Polycation-Mediated Introduction of DNA into Human Leukemic Cells: Stimulation by Agents that Affect the Survival of Transfected DNA or Modulate Transferrin Receptor Levels," 87 Proc. Natl. Acad. Sci. USA 4033, 1990.
Curiel et al., "Gene Transfer to Respiratory Epithelial Cells via the Receptor-Mediated Endocytosis Pathway," 6 Am. J. Respir. Cell Mol. Biol. 247, 1992.
Curiel et al., "Adenovirus Enhancement of Transferrin-Polylysine-Mediated Gene Delivery,"88 Proc. Natl. Acad. Sci. USA 8850, 1991.
Dennis et al., "Structure-Activity Profile of Calcitonin Gene-Related Peptide in Peripheral and Brain Tissues. Evidence for Receptor Multiplicity," 251 J. Pharm. Exper. Ther. 718, 1989.
Dingwall and Laskey, "Nuclear Targeting Sequences -- a Consensus?", 16 Trend in Biochem. Sc 478, 1991.
Distler et al., "The Binding Specificity of High and Low Molecular Weight Phosphomannosyl Receptors from Bovine Testes," 266 J. Biol. Chem. 21687, 1991.
Durland et al., "Binding of Triple Helix Forming Oligonucleotides to Sites in Gene Promoters," 30 Biochemistry 9246, 1991.
Dyer et al., "A Synthetic Peptide Mimic of Plasma Apolipoprotein E that Binds the LDL Receptor," 266 J. Biol. Chem. 22803, 1991.
Feener et al., "Cleavage of Disulfide Bonds in Endocytosed Macromolecules," 265 J. Biol. Chem. 18780-18785, 1990.
Felgner et al., "Gene Therapeutics," 349 Nature 351, 1991.
Foyt et al., "The IFG-I Gene: Structure, Expression, and Gene Products," In: Insulin-Like Growth Factors: Molecular and Cellular Aspects, CRC Press (1991).
Friedman, "Progress Toward Human Gene Therapy," 244 Science 1275, 1989.
Garcia-Bustos et al., "Nuclear Protein Localization," 1071 Biochim. Biophys. Acta 83, 1991.
Geoffroy et al., "Alveolysin, the Thiol-Activated Toxin of Bacillus alvei, Is Homologous to Listeriolysin O, Perfringolysin O, Pneumolysin, and Streptolysin O and Contains a Single Cysteine," 172 J. Bacteriol. 7301, 1990.
Gilardi et al., "Expression of Human .alpha..sub.1 -Antitrypsin Using a Recombinant Adenovirus Vector," 267 FEBS 60, 1990.
Goldfard et al., "Synthetic Peptides as Nuclear Localization Signals," 322 Nature 641, 1986.
Goldstein et al., "Coated Pits, Coated Vesicles, and Receptor-Mediated Endocytosis," 279 Nature 679, 1979.
Hardy et al., "Different Modes of Ligand Binding to the Hepatic Galactose/N-Acetygalactosamine Lectin on the Surface of Rabbit Hepatocytes," 24 Biochemistry 22, 1985.
Henderson, "Folate-Binding Proteins," 10 Annu. Rev. Nutr. 319, 1990.
Hobbs et al., "The LDL Receptor Locus in Familial Hypercholesterolemia: Mutational Analysis of a Membrane Protein," 24 Annu. Rev. Genet. 133, 1990.
Ichikawa et al., "Synthesis of a Branched Glycopeptide Derivative Containing Terminal .sub.D -Mannose 6-Phosphate Residues," 198 Carbohydrate Research 235, 1990.
Inman et al., "Controlled Primary Functionalization of Agarose Affinity Supports by Carboxymethylation and Subsequent Addition of Spacer Units," 376 J. Chromat. 273, 1986.
Israel et al., "Analogs of Spermine and Spermidine," 94 Methods in Enzymology 411, 1983.
Jaffe et al., "Adenovirus-Mediated In Vivo Gene Transfer and Expression in Normal Rat Liver," 1 Nature-Genetics 372, 1992.
Jennings et al., "Chick Myotubes in Culture Express High-Affinity Receptors for Calcitonin Gene-Related Peptide," 504 Brain Research 199, 1989.
Kaleko et al., "Persistent Gene Expression After Retroviral Gene Transfer into Liver Cells In Vivo," 2 Human Gene Therapy 27, 1991.
Kempen et al., "A Water-Soluble Cholesteryl-Containing Trisgalactoside: Synthesis, Properties, and Use in Directing Lipid-Containg Particles to the Liver," 27 J. Med. Chem. 1306, 1984.
Kiess et al., "Insulin-Like Growth Factor-II (IGF-11) Inhibits Both the Cellular Uptake of .beta.-Galactosidase and the Binding of .beta.-Galactosidase to Purified IGF-II/Mannose 6-Phosphate Receptor," 264 J. Biol. Chem. 4710, 1989.
Lanford et al., "Effect of Basic and Nonbasic Amino Acid Substitutions on Transport Induced by Simian Virus 40 T-Antigen Synthetic Peptide Nuclear Transport Signals," 8 Mol. Cell. Biol. 2722, 1988.
Leamon and Low, "Delivery of Macromolecules into Living Cells: A Method that Exploits Folate Receptor Endocytosis," 88 Proc. Natl. Acad. Sci. USA 5572, 1
Cristiano Richard J.
Gottchalk Stephen
Smith Louis C.
Sparrow Jim
Woo Savio L. C.
Baylor College of Medicine
Brusca John S.
LaGuyader John L.
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