Nucleic acid structure with protonated cytosine-cytosine base pa

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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C07H 2100

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056250517

ABSTRACT:
An `i-motif` nucleic acid, DNA and/or RNA, complex characterized by the presence of at least four cytosine-rich stretches or stretches rich in cytosine derivatives, including two parallel-stranded duplexes in which the cytosines or derivatives thereof form base pairs, said two duplexes being associated anti-parallel to one another, and said pairs of cytosine or derivatives thereof of one duplex being intercalated with those of the other duplex.

REFERENCES:
Uhlmann et al (1990) Chem. Rev. 90(4), 543-584.
Milligan et al. (1993) J. Med. Chem, 36(14), 1923-1937.
Leroy et al. (1993) Biochem. 32, 6019-6031.

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