Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Reexamination Certificate
2005-04-19
2005-04-19
Sisson, Bradley L. (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
C435S006120, C435S091100, C435S091200, C435S091210, C435S183000, C435S810000, C536S024330
Reexamination Certificate
active
06881537
ABSTRACT:
The present invention is related to nucleic acid sequences that can be used in the field of virus diagnostics, more specifically the diagnosis of infections with the AIDS causing Human Immuno-deficiency Virus (HIV).With the present invention nucleotide sequences are provided that can be used as primers and probes in the amplification and detection of HIV-1 nucleic acid. The oligonucleotide sequences provided with the present invention are located in the LTR part of the HIV viral genome. It has been found that, by using the sequences of the present invention in methods for the amplification and detection of nucleic acid a sensitive and specific detection of HIV-1 can be obtained. The benefit of the sequences of the present invention primarily resides in the fact that, with the aid of primers and probes comprising the sequences according to the invention the nucleic acid of all presently known subtypes of HIV-1 can be detected with high accuracy and sensitivity. So far no primer pairs or hybridization probes have been developed that would allow the detection of such a broad range of HIV-1 variants.The oligonucleotide sequences according to the present invention are especially useful in methods for the amplification of nucleic acid.
REFERENCES:
patent: 5221610 (1993-06-01), Montagnier et al.
patent: 5306631 (1994-04-01), Harrison et al.
patent: 5474796 (1995-12-01), Brennan
patent: 5576176 (1996-11-01), Adams et al.
patent: 5629413 (1997-05-01), Peterson et al.
patent: 5712385 (1998-01-01), McDonough et al.
patent: 5770428 (1998-06-01), Boris-Lawrie
patent: 6001558 (1999-12-01), Backus et al.
patent: 6025124 (2000-02-01), Adams et al.
patent: 0 331 939 (1989-09-01), None
patent: 0 331 939 (1989-09-01), None
patent: 0 402 997 (1990-12-01), None
patent: 0 402 997 (1990-12-01), None
patent: 0617132 (1993-09-01), None
patent: 0 617 132 (1994-09-01), None
patent: 0 617 132 (1994-09-01), None
patent: 0 727 497 (1996-08-01), None
patent: 0 887 427 (1998-12-01), None
patent: WO 91 10746 (1991-07-01), None
patent: WO 9110746 (1991-07-01), None
“Designer PCR” computer program (advertisement), by Research Genetics, Nucleic Acid Research, vol. 22, No. 15, Aug. 1994.*
De Baar et al., Journal of Clinical Microbiology, vol. 37, No. 6, Jun. 1999, pp. 1813-1818.*
Zaaijer et al., Journal of Virological Methods, vol. 52, 1995, pp. 175-181.*
Research Genetics, “Designer PCR”, Nucleic Acids Research, vol. 22, No. 15, Aug. 1994.*
Research Genetics, “Designer PCR,” (advertisement) Nucleic Acids Research, vol. 22, No. 15, Aug. 1994.*
Advertisement of Research Genetics for “Designer PCR”, Nucleic Acids Research, vol. 22, No. 15, Aug. 11, 1994.*
Research Genetics (advertisement), Nucleic Acids Research, vol. 22, No. 15, Aug. 1994.*
Bell and Ratner “Specificity of Polymerase Chain Amplification Reactions for Human Immunodeficiency Virus Type 1 DNA Sequences”AIDS Research and Human Retroviruses5(1):87-95 (1989).
Böni et al. “PCR Identification of HIV-1 DNA Sequences in Brain Tissue of Patients with AIDS Encephalopathy”Neurology43:1813-1817 (1993).
Goto et al. “Detection of Proviral Sequences in Saliva of Patients Infected with Human Immunodeficiency Virus Type 1”AIDS Research and Human Retroviruses7(3):343-347 (1991).
Karikó “Identification of Conserved Sequences for PCR Primer Design by Multiple Alignments of Dot Matrix Plots”BioTechniques18(6):1048-1049 (1995).
Map of 5′ LTR from HIV-1 reference genome (GenBank Accession No. K03455).
Oehlenschlager et al. “Detection of HIV-1 RNA by Nucleic Acid Sequence-Based Amplification Combined with Fluorescence Correlation Spectroscopy”Proc. Natl. Acad. Sci. USA93:12811-12816 (1996).
Scientific Report on Computer Analysis of the Alignment of the HIV LTR Sequence from the Dec. 1996 Edition of the Human Retroviruses and AIDS Compendium published by the Los Alamos National Laboratory, New Mexico.
Revets et al. “Comparative Evaluation of NASBA HIV-1 RNA QT, Amplicor-HIV Monitor, and Quantiplex HIV RNA Assay, Three Methods for Quantification of Human Immunodeficiency Virus Type 1 RNA in Plasma”Journal of Clinical Microbiology34(5):1058-1064 (1996).
LTR alignment from the Dec. 1996 Edition of the Human Retroviruses and AIDS Compendium published by the Los Alamos National Laboratory, New Mexico.
Partial gag alignment from the Dec. 1996 Edition of the Human Retroviruses and AIDS Compendium published by the Los Alamos National Laboratory, New Mexico.
Van Gemen et al. “Quantification of HIV-1 RNA in Plasma Using NASBA™ During HIV-1 Primary Infection”Journal of Virological Methods43:177-188 (1993).
File history of European patent application serial No. EP 98943872.6, filed Aug. 5, 1998.
Teglbjaerg et al., “Sensitive non-radioactive detection of HIV-1: use of nested primers for the amplification of HIV DNA” Molecular and Cellular Probes (1992) 6: p. 175-180.
“Quantification of HIV-1 Using Multiple Competitors in a Single-Tube Assay” BioTechniques, vol. 21, No. 2 (1996) p. 248-255.
Zazzi et al., “Nested Polymerase Chain Reaction for Detection of Human Immunodeficiency Virus Type 1 DNA in Clinical Specimens” Journal of Medical Virology 32: (1992) p. 172-174.
Engelbrecht et al., “Detection of Southern African human immunodeficiency virus type 1 subtypes by polymerase chain reaction: evaluation of different primer pairs and conditions” Journal of Virological Methods, 55 (1995) p. 391-400.
Innocenti et al., “HIV-1 in Blood Monocytes: Frequency of Detection of Proviral DNA using PCR and Comparison with the Total CD4 Count” AIDS Research and Human Retroviruses, vol. 8, No. 2, (1992) p. 261-268.
Ottmann et al., “The Polymerase chain reaction for the detection of HIV-1 genome RNA in plasma from infected individuals” Journal of Virological Methods, 31 (1991) p. 273-284.
Quiros et al., “Human immunodeficiency virus type-1 can be detected in monocytes by polymerase chain reaction” J. Med. Microbiol., vol. 42, (1995), p. 411-414.
McCutchan et al., “Genetic Comparison of Human immunodeficiency Virus (HIV-1) Isolates by Polyermase Chain Reaction” Journal of Acquired Immune Deficiency Syndrome 4, (1991) p. 1241-1250.
Goudsmit Jaap
Jurriaans Suzanne
Lukashov Vladimir Vladimirovich
Oudshoorn Pieter
bioMérieux, B.V.
Myers, Sigel, Sibley & Sajovec, P.C.
Sisson Bradley L.
LandOfFree
Nucleic acid sequences that can be used as primers and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid sequences that can be used as primers and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid sequences that can be used as primers and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3383725