Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Patent
1994-02-22
1997-10-28
Chambers, Jasemine C.
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
435375, 435 697, 4351723, 435 6, 935 62, 935 34, 935 70, 536 242, C12N 1563, C12N 500, C07H 2104
Patent
active
056817479
ABSTRACT:
New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase C.alpha.. Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase C.alpha.. Oligonucleotides are provided which are specifically hybridizable with nucleic acid encoding PKC.alpha.. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed. Polynucleotide probes for PKC.alpha. are also disclosed.
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Boggs Russell T.
Dean Nicholas M.
Chambers Jasemine C.
Hauda Karen M.
ISIS Pharmaceuticals Inc.
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