Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Isomerase
Reexamination Certificate
2007-07-03
2007-07-03
Steadman, David J. (Department: 1656)
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Isomerase
C435S183000, C435S069100, C435S068100, C435S320100, C435S325000, C435S419000, C435S252300, C435S254110, C536S023200
Reexamination Certificate
active
11216937
ABSTRACT:
Protein disulfide isomerase is a major component ofConusvenom ducts. The invention relates to a protein disulfide isomerase (PDI) fromConussnails, a nucleic acid sequence encoding theConusprotein disulfide isomerase, and to methods for folding disulfide-rich peptides using a protein disulfide isomerase. Oxidative folding of conotoxin precursors, catalyzed by a PDI, was more efficient and decreased the number and concentration of transiently accumulated folding species. The PDI-assisted oxidative folding of conotoxins was also influenced by the propeptide relative to the mature peptide.
REFERENCES:
patent: 6346244 (2002-02-01), Hjort
patent: 0 510 658 (1992-10-01), None
patent: WO 93/25676 (1993-12-01), None
patent: WO 94/08012 (1994-04-01), None
patent: WO 95/01420 (1995-01-01), None
patent: WO 95/01425 (1995-01-01), None
patent: WO 97/14431 (1997-04-01), None
patent: WO 97/43426 (1997-11-01), None
patent: WO 99/46281 (1999-09-01), None
patent: WO 01/14564 (2001-03-01), None
patent: WO 02/20731 (2002-03-01), None
Folding of ro-Conotoxins. 2. Influence of Precursor Sequences and Protein Disulfide Isomerase. Marian Price-Carter, William R. Gray, and David P. Goldenberg. Sep. 1996. Biochemistry 1996, 35, 15547-15557.
Karplus et al., Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure, J. Mol. Biol., Nov. 2, 2001, pp. 903-919, vol. 313, No. 4, Abstract.
IBA et al., Comparison of strategies for the construction of libraries of artificial antibodies, Immunol. Cell Biol., Apr. 1997, pp. 217-221, vol. 75, No. 2, Abstract.
Jayawickreme et al., Creation and functional screening of a multi-use peptide library, Proc. Natl. Acad. Sci., Mar. 1994, pp. 1614-1617, vol. 91, USA.
Klug, A, Zinc finger peptides for the regulation of gene expression, J. Mol. Biol., Oct. 22, 1999, pp. 215-218, vol. 293, No. 2.
Ogiwara et al., Construction and analysis of a profile library characterizing groups of structurally known proteins, Protein Sci., Oct. 1996, pp. 1991-1999, vol. 5, No. 10.
Saunder et al., Large-Scale Comparison of Protein Sequence Alignment Algorithms With Structure Alignments, Proteins: Structure, Function, and Genetics, 2000, pp. 6-22, vol. 40.
Schaffer et al., Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements, Nucleic Acids Research, 2001, pp. 2994-3005, vol. 29, No. 14, USA.
Smith et al., Small Binding Proteins Selected form a Combinatorial Repertoire of Knottins Displayed on Phage, J. Mol. Biol., 1998, pp. 317-332, vol. 277.
Valuev et al., ASPD (Artificially Selected Proteins/Peptides Databases): a database of proteins and peptides evolved in vitro, Nucleic Acids Research, 2002, pp. 200-202, vol. 30, No. 1.
Yamauchi et al., Bovine Protein Disulfide Isomerase. 1998. Accession AAP80615.
Toyoshima et al., Polypeptides with Protein Disulfide Activity. Accession AAP80664, 2002.
Buczek Olga
Bulaj Grzegorz
Garrett James E.
Goodsell Ian
Olivera Baldomero M.
Cognetix, Inc.
Gebreyesus Kagnew
Steadman David J.
TraskBritt
University of Utah Research Foundation
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