Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2006-08-29
2006-08-29
Ulm, John (Department: 1649)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C436S501000
Reexamination Certificate
active
07097991
ABSTRACT:
The present invention features vanilloid receptor polypeptides and vanilloid receptor-related polypeptides, specifically the capsaicin receptor subtypes VR1 and VR2 (VRRP-1), as well as the encoding polynucleotide sequences. In related aspects the invention features expression vectors and host cells comprising such polynucleotides. In other related aspects, the invention features transgenic animals having altered capsaicin receptor expression, due to, for example, the presence of an exogenous wild-type or modified capsaicin receptor-encoding polynucleotide sequence. The present invention also relates to antibodies that bind specifically to a capsaicin receptor polypeptide, and methods for producing these polypeptides. Further, the invention provides methods for using capsaicin receptor, including methods for screening candidate agents for activity as agonists or antagonists of capsaicin receptor activity, as well as assays to determine the amount of a capsaicin receptor-activating agent in a sample. In other related aspects, the invention provides methods for the use of the capsaicin receptor for the diagnosis and treatment of human disease and painful syndromes.
REFERENCES:
patent: 5074977 (1991-12-01), Cheung et al.
patent: 5232684 (1993-08-01), Blumberg et al.
patent: 5234566 (1993-08-01), Osman et al.
patent: 5328847 (1994-07-01), Case et al.
patent: 5443955 (1995-08-01), Cornell et al.
patent: 5491097 (1996-02-01), Ribi et al.
patent: 6239267 (2001-05-01), Duckworth et al.
patent: 6335180 (2002-01-01), Julius et al.
patent: 0953638 (1999-03-01), None
patent: 0943 683 (1999-09-01), None
patent: 0953638 (1999-11-01), None
patent: 1 160 254 (2001-05-01), None
patent: WO 99/37765 (1999-07-01), None
patent: WO 99/46377 (1999-09-01), None
patent: WO 00/29577 (2000-05-01), None
patent: WO 00/32766 (2000-06-01), None
patent: WO 00/63415 (2000-10-01), None
patent: WO 01/34805 (2001-05-01), None
patent: WO 01/68857 (2001-09-01), None
Appendio and Szallasi, AEuphorbium: Modern Research on its Active Principle, Resiniferatoxin, Revives an Ancient Medicine, @Life Sciences,60(10): 681-696 (1997).
Bevan and Szolcsányi, ASensory Neuron-Specific Actions of Capsaicin: Mechanisms and applications,@Tips,vol. 11 (Aug. 1990).
Bevan and Docherty,Capsaicin in the Study of Pain,Chapter 2: ACellular Mechanisms of the Action Capsaicin,@ pp. 27-44. Academic Press Ltd. (1993).
Fusco and Giacovazzo, APeppers and Pain,@ Drugs, 53(6): 909-914 (Jun. 1997).
Campbell, et al.,Capsaicin in the Study of Pain,Chapter 12: AClinical Applications of Capsaicin and Its Analogues,@ pp. 255-273. Academic Press Ltd. (1993).
Caterina, et al., “The Capsaicin Receptor: A Heat-Activated Ion Channel in the Pain Pathway,”Nature389:816-824 (Oct. 23, 1997).
James, et al., Capsaicin in the Study of Pain, Chapter 5: AThe Capsaicin Receptor,@ pp. 83-104. Academic Press Ltd. (1993).
Koplas, et al, AThe Role of Calcium in the Desensitization of Capsaicin Responses in Rat Dorsal Root Ganglion Neurons,@Journal of Neuroscience,17(10): 3525-3537 (May 15, 1997).
Liu, et al., AThe Responses of Rat Trigeminal Ganglion Neurons to Capsaicin and Two Nonpungent Vanilloid Receptor Agonists, Olvanil and Glycerlyl Nonamide,@Journal of Neuroscience,17(11): 4101-4111 (Jun. 1, 1997).
Nagy, et al., “Cobalt Uptake Enables Identification of Capsaicin- and Bradykinin-Sensitive Supopulations of Rat Dorsal Root Ganglion Cells In Vitro,”Neuroscience56(1):241-246 (1993).
Rang, et al., Textbook of Pain, Chapter 3: ANociceptive Peripheral Neurons: Cellular Properties,@ pp. 57-78.
A. Maureen Rouhi, AChili Pepper Studies Paying off with Hot Birdseed and Better Analgesics,@Chemical and Engineering News,pp. 30-31 (Mar. 4, 1996).
J. Szolcsányi,Capsaicin in the Study of Pain,Chapter 1: AActions of Capsaicin on Sensory Receptors,@ pp. 1-26, Academic Press Ltd. (1993).
Towheed and Hochberg, AA Systematic Review of Randomized Controlled Trials of Pharma-cological Therapy in Osteoarthritis of the Knee, with an Emphasis on Trial Methodology,@Semin. Arthritis Rheum.26(5): 755-770 (Apr. 1997).
Wood, et al., ACapsaicin-Induced Ion Fluxes Increase Cyclic GMP But Not Cyclic AMP Levels in Rat Sensory Neurons in Culture,@Journal of Neurochemistry,53(4): 1203-1211 (1989).
GenBank Accession No. H20025.
GenBank Accession No. AA236416.
GenBank Accession No. H51393.
GenBank Accession No. AA236417.
GenBank Accession No. H27879.
GenBank Accession No. H50364.
GenBank Accession No. N21167.
GenBank Accession No. AA461295.
GenBank Accession No. N26729.
GenBank Accession No. H21490.
GenBank Accession No. H49060.
GenBank Accession No. AA281349.
GenBank Accession No. W44731.
GenBank Accession No. N23395.
GenBank Accession No. W38665.
GenBank Accession No. AA357145.
GenBank Accession No. N24224.
GenBank Accession No. W92895.
GenBank Accession No. T12251.
GenBank Accession No. AA304033.
GenBank Accession No. N35179.
GenBank Accession No. AA281348.
GenBank Accession No. W82502.
GenBank Accession No. W53556.
GenBank Accession No. AA139413.
GenBank Accession No. AA76107.
GenBank Accession No. AA015295.
GenBank Accession No. AA274980.
GenBank Accession No. AA321554.
Szallasa, et al., “Characterization of a Peripheral Vanilloid (Capsaicin) Receptor in the Urinary Bladder of the Rat,”Life Science52(20):221-226 (1993).
Wardle, et al., “Pharmacological Characterization of the Vanilloid Receptor in the Rat Isolated Vas Deferens,”J. Pharm. Pharmacol.48:285-291 (1996).
Biro et al. (1997) “Recent Advances in Understanding of Vanilloid Receptors: A Therapeutic Target for Treatment of Pain and Inflammation in Skin.”Journal of Investigative Dermatology Symposium Proceedings,vol. 2:56-60.
Szallasi (1994) “The Vanilloid (Capsaicin) Receptor: Receptor Types and Species Difference.”Gen. Pharmac.,vol. 25(2):223-243.
Brake Anthony J.
Caterina Michael J.
Julius David J.
Borden Paula A.
Bozicevic Field & Francis LLP
The Regents of the University of California
Ulm John
LandOfFree
Nucleic acid sequences encoding capsaicin receptor and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid sequences encoding capsaicin receptor and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid sequences encoding capsaicin receptor and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3642791