Chemistry: molecular biology and microbiology – Spore forming or isolating process
Patent
1989-01-24
1993-08-10
Nucker, Christine M.
Chemistry: molecular biology and microbiology
Spore forming or isolating process
530395, 530827, 435 701, 435 703, 536 235, C12N 1512, C12N 506, C12N 508
Patent
active
052350495
ABSTRACT:
The present invention relates to a soluble form of intercellular adhesion molecule (sICAM-1) and purified and isolated human sICAM-1. This invention also relates to a purified and isolated DNA sequence encoding sICAM-1. The extracellular domain of sICAM-1 and insoluble ICAM-1 are substantially the same. ICAM-1 is involved in the process through which lymphocytes attach to cellular substrates during inflammation and serves as the major human rhinovirus receptor (HRR). sICAM-1 therefore has both the property of reducing immune inflammation and inhibiting infection of rhinovirus and Coxsackie A virus.
REFERENCES:
Nature, vol. 331, No. 6157, Feb. 1988, D. Simmons et al., ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM, pp. 624-627.
Cell, vol. 52, No. 6, Mar. 25, 1988, D.E. Staunton et al. Primary Structure of ICAM-1 Demonstrates Interaction between Members of the Immunoglobulin and Intergrin Supergene Families, pp. 925-933.
Journal of Virology, vol. 58, No. 2, May 1986, pp. 290-295, J.E. Tomassini et al.; Isolation of a receptor protein involved in attachment of human rhinoviruses.
Cell, vol. 52, Mar. 25, 1988, pp. 925-933, Cell Press, D.E. Staunton et al.; Primary Structure of ICAM-1 demonstrates interaction between members of the immunoglulin and integrin supergene familes.
Cell vol. 51, Dec. 4, 1987, pp. 813-819, Cell Press, S.D. Marlin et al.; Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1).
The Journal of Immunology, vol. 137, No. 4, Aug. 15, 1986, pp. 1270-1274, The American Association of Immunologists, R. Rothlein et al.; A Human Intercellular adhesion molecule (ICAM-1) distinct from LFA-1.
Nature, vol. 331 Feb. 18, 1988, pp. 624-627, D. Simmons et al.; ICAM, an adhesion ligand of LFA-1, is homologous to the neural cell adhesion molecule NCAM.
Greve Jeffrey M.
McClelland Alan
Cunningham T.
Molecular Therapeutics, Inc.
Nucker Christine M.
LandOfFree
Nucleic acid sequences encoding a soluble molecule (SICAM-1) rel does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid sequences encoding a soluble molecule (SICAM-1) rel, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid sequences encoding a soluble molecule (SICAM-1) rel will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1726376