Nucleic acid sequences associated with cell states

Details Nucleic acid sequences associated with cell states Nucleic acid sequences associated with cell states

2011-01-11

2011-01-11

Martinell, James (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100, C435S091200

Reexamination Certificate

active

07867712

ABSTRACT:
The present invention is directed to nucleic acid sequences whose expression is associated with different cell states, including nucleic acid sequences whose expression is induced at least 100-fold, or alternatively upregulated, in cells exhibiting asymmetric self-renewal relative to other cells. The invention is also directed to nucleic acid sequences whose expression is induced at least 100-fold, or alternatively upregulated, in cells exhibiting symmetric self-renewal relative to other cells.

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Bhat, Krishna M. and Nora Apsel, “Upregulation of Mitimere and Nubbin acts through Cyclin E to confer self-renewing asymmetric division potential to neural precursor cells” Development (2004) vol. 131 No. 5, pp. 1123-1134.
Fortunel et al., “Comment on “Sternness”: Transcriptional Profiling of Embryonic and Adult Stem Cells” and “A Stem Cell Molecular Signature” (I) Science (2003) vol. 302 p. 393 (3 pgs.).
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