Nucleic acid sequences and proteins involved in cellular...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology

Reexamination Certificate

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C435S069100

Reexamination Certificate

active

07001769

ABSTRACT:
The present invention relates to nucleic acid sequences and proteins involved in senescence and particularly, to nucleic acid sequences and proteins including amphiphysin and caveolin involved in cellular senescence and their use.

REFERENCES:
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Gorecki, Prospects and Problems of Gene Therapy: An Update. Exp. Opin. Emerging Drugs. 2001, vol. 6(2), pp. 187-98.
Verma, et al. Gene Therapy- Promises, Problems and Prospects. Nature. 1997, vol. 389:, pp. 239-242.
Eck, et al. Gene-Based Therapy. In Goodman & Gilman's The Pharmacological Basis of Therapeutics, 1996, 9th Ed., McGraw-Hill, New York, NY., pp. 77-101.
David et al. Autoimmunity in Stiff-Man Syndrome with Breast Cancer is Targetedd to the C-Terminal Region of Human Amphiphysin, a Protein Similar to the Yeast Proteins, Rvs167 and Rvs 161. FEBS Letters, 1994, vol. 351, pp. 73-79.
W.-Y.- Park et al; “Up-regulation of Caveolin Attenuates Epidermal Growth Factor Signaling in Senescent Cells”, J. Biol. Chem., vol. 275 (27), Jul. 7, 2000 pp. 20847-20852.

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