Combinatorial chemistry technology: method – library – apparatus – Apparatus specially adapted for use in combinatorial... – For identifying a library member
Reexamination Certificate
2011-07-26
2011-07-26
Gross, Christopher M (Department: 1639)
Combinatorial chemistry technology: method, library, apparatus
Apparatus specially adapted for use in combinatorial...
For identifying a library member
C506S003000, C435S006120
Reexamination Certificate
active
07985716
ABSTRACT:
Multiplexed affinity purification and thermal dissociation prior to biochip hybridization simplifies uncharacterized sample admixtures, thereby minimizing or eliminating sample interferents, improving hybridization specificity on a microarray detector, and minimizing or eliminating the need for post-hybridization thermal dissociation analysis. An integrated thermo-affinity sample preparation sub-circuit for sample purification and enrichment is described that is consistent with a field-portable form factor and analytical processes. Thermo-affinity sample preparation on model admixtures of varying complexity was efficacious.
REFERENCES:
patent: 2003/0190608 (2003-10-01), Blackburn
patent: 2010/0216657 (2010-08-01), Hukari et al.
Chandler Darrell P.
Chernov Boris K.
Golova Julia B.
Kukhtin Alexander
Yershov Gennadiy M.
Barnes & Thornburg LLP
Gross Christopher M
Martin Alice O.
UChicago Argonne LLC
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