Nucleic acid respiratory syncytial virus vaccines

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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435 914, 4353201, A61K 3170, C12N 1564, C12N 1585

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active

058439137

ABSTRACT:
Vectors containing a nucleotide sequence coding for an F protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described. Such vectors also may contain a further nucleotide sequence located adjacent to the RSV F protein encoding sequence to enhance the immunoprotective ability of the RSV F protein when expressed in vivo. Such vectors may be used to immunize a host, including a human host, by administration thereto. Such vectors also may be used to produce antibodies for detection of RSV infection in a sample.

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Wathen et al. (1989) Immunization of cotton rats with the human respiratory syncytial virus F glycoprotein produced using a baculovirus vector. J. Infect. Dis. 159:255-264. Feb. 1989.
Collis et al. (1990) Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression. EMBO J. 9:233-240. Jan. 1990.
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