Nucleic acid respiratory syncytial virus vaccines

Details Nucleic acid respiratory syncytial virus vaccines Nucleic acid respiratory syncytial virus vaccines

1997-07-18

2000-01-25

Degen, Nancy

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

4353201, A61K 3170, C12N 1585

Patent

active

060178973

ABSTRACT:
Non-replicating vectors containing a nucleotide sequence coding for an F protein of respiratory syncytial virus (RSV) and a promoter for such sequence, preferably a cytomegalovirus promoter, are described for in vivo immunization. Such non-replicating vectors, including plasmids, also may contain a further nucleotide sequence located adjacent to the RSV F protein encoding sequence to enhance the immunoprotective ability of the RSV F protein when expressed in vivo. Such non-replicating vectors may be used to immunize a host against disease caused by infection with RSV, including a human host, by administration thereto, and may be formulated as immunogenic compositions with pharmaceutically-acceptable carriers for such purpose. Such vectors also may be used to produce antibodies for detection of RSV infection in a sample.

REFERENCES:
patent: 5149650 (1992-09-01), Wertz et al.
patent: 5589466 (1996-12-01), Felgner et al.
McIntosh, K. Et al In: Fields BN, Knipe, DM, editors. Virology, New York: Raven Press 1990: 1045-1072.
Wertz, G.W. et al, Biotechnology 1992, 20: 151-176.
Johnson et al., J. Virol. 1987, 61: 3163-3165.
Crowe, J.E., Vaccine 1995, 13: 415-421.
Ulmer, Current Opinion, Invest Drugs, 1993, 2: 983-989.
Tang et al., Nature 1992, 356: 152-154.
Furth et al. Analytical Biochemistry, 1992, 205: 365-368.
Chapman, B.S. et al, Nucl. Acids Res. 1991, 19: 3979-3986.
Graham, B.S. et al., J. Mod. Virol. 1988 26: 153-162.
Nabel, G.J. et al Proc. Natl. Acad. Sci. USA 90:11307-11311, 1993.
Du, R.P. et al 1994, Biotechnology 12: 813-818.
Prince, G.A. et al, 1978. Ame J. Pathol. 93: 771-790.
Davis et al, Vaccine 1994, 12: 1503-1509.
Chanock, Robert M. et al, Pediatrics vol. 90 No. 1, Jul. 1992, pp. 137-142.
Groothuis et al, N. Engl. J. Med. 329:1524-1530, 1993.
Walsh et al, J. Infec. Dis., 155: 1198-1204, 1987.
Lounsbach et al, Journal of General Virology 74, 2559-2565 (1993).
Wathen et al, J. Infect. Dis. 159: 255-264 (1989).
Wertz et al, J. Virol 61: 293-301 (1987).
Tang et al (1993) J. Biol. Chem. 268:9522-9525.
Collis et al (1990) Embo J. 9:233-240.

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