Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1993-10-27
1995-11-14
Parr, Magaret
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 2432, 536 2433, 435 912, C12Q 168
Patent
active
054665779
ABSTRACT:
Nucleic acid probes are described for detecting bacteria capable of causing Lyme disease. These probes complement the ribosomal ribonucleic acid sequences unique to Borrelia spirochetes, and as such can detect the rRNA, rDNA, or polymerase chain reaction amplification products of these genes. These probes, plus the described amplification primers, can be used to detect the etiological agent of Lyme disease in human or veterinary samples, and for determining the infective potential of Ixodes ticks.
REFERENCES:
patent: 4683195 (1989-07-01), Mullis et al.
LeFebvre et al., J. Clin. Microbiol. 27(4):636-9, Apr. 1989.
Matthews et al. Analytical Biochem. 169: 1-25, 1988 (Feb. 1988).
Goodman et al., "A Unique DNA Clone Specific for Bonelia . . . ", Clinical Research, vol. 37(2), p. 429A, (1989).
Schwane et al., "Efficacy of Nucleic Acid Hybridization . . . ", Annals of the New York Academy of Sciences, vol. 539, pp. 419-421 (1988).
Schwan et al., "Identification of Borrelia burgdorferi . . . " Journal of Clinical Microbiology, vol. 27, No. 8, pp. 1734-1738 (1989, Aug.).
Burgdorfer et al., Science 216:1317-1319, 1982.
Johnson et al., Int. J. Syst. Bacteriol. 34:496-497, 1984.
Kohne et al., Biophysical Journal 8:1104-1118, 1968.
Pace and Campbell, Journal of Bacteriology 107:543-547, 1971.
Sogin, Sogin and Woese, Journal of Molecular Evolution 1:173-184, 1972.
Fox, Pechman and Woese, International J. of Syst. Bacteriology 27:44-57, 1977.
Chemical Abstracts, vol. 107, No. 9, Aug. 31, 1987, p. 362, abstract No. 73936x, Columbus, Ohio, US; L. Hayes et al.: "A short peptide sequence is conserved between three tick-borne Borrelia," & Biochem. Soc. Trans. 1987, 15(4), 644 *Abstract*.
Chemical Abstracts, vol. 112, No. 9, Feb. 1990, p. 410, abstract No. 73093y, Columbus, Ohio, US; P. A. Rosa et al.: "A specific and sensitive assay for the Lyme disease spirochete Borrelia burgdorferi using the polymerase chain reaction," J. Infect. Dis. 1989, 160(6), 1018-29 *Abstract*.
Chemical Abstracts, vol. 110, No. 21, May 1989, p. 406, abstract No. 189215c, Columbus, Ohio, US; R. B. LeFebvre et al.: "Characterization of Borrelia burgdorferi isolates by restriction endonuclease analysis and DNA hybridization," & J. Clin. Microbiol. 1989, 27(4), 636-9 *Abstract*.
Chemical Abstracts, vol. 113, No. 5, Jul. 30, 1990, p. 294, abstract No. 37190q, Columbus, Ohio, US; D. C. Malloy et al.: "Detection of Borrelia burgdorferi using the polymerase chain reaction," & J. Clin. Microbiol. 1990, *Abstract*.
Biological Abstracts, vol. 88, No. 7, Apr. 1989, abstract No. 75033, Philadelphia, Pa., US; T. G. Schwan et al. "Identification probes," & J. Clin. Microbiol. 27(8): 1734-1738. 1989 *Abstract*.
J. Clin. Chem. Biochem., vol. 25, No. 9, 1987, p. 573; U. B. Gobel et al.: "Synthetic oligodeoxynucleotides complementary to ribosomal RNA as probes for rapid detection & identification of fastidious pathogenic bacteria" *Whole article*.
Amoco Corporation
Galloway Norval B.
Houtteman Scott William
Parr Magaret
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