Nucleic acid probes and methods for detecting cryptococcus neofo

Details Nucleic acid probes and methods for detecting cryptococcus neofo Nucleic acid probes and methods for detecting cryptococcus neofo

1992-07-01

1995-11-07

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 2432, 536 2433, 935 77, 935 78, 435 912, C12Q 168, C07H 2104, C12P 1934

Patent

active

054647436

ABSTRACT:
Nucleic acid probes are described for detecting yeasts capable of causing cryptococcosis, specifically Cryptococcus neoformans. The preferred probes are complementary to the ribosomal ribonucleic acid sequences unique to Cryptococcus neoformans, and as such can detect the rRNA, rDNA, or polymerase chain reaction amplification products of these genes. The detection of the etiological agent of human cryptococcosis, and tests for making a clinical diagnosis of this disease utilizing specific rRNA or rDNA probes are now possible.

REFERENCES:
Biosis Abstract No. 88130563, Restrepo et al, J. Bacteriol., 171(10), 1989 pp. 5596-5600.
Forman et al., Abstract of Mol. Cell. Biol., 9, 1989, pp. 1137-1147.
Japanese Patent No. 62104583, Abstract, May 15, 1987.
Japanese Patent No. 62104582, Abstract, May 15, 1987.
European Patent No. 289478, Abstract, Nov. 2, 1988.
Aulakh et al., Int. J. Syst. Bacteriol., Jan. 1981, pp. 97-103.
Restrepo et al. (Oct. 1989) & Bacteriol. 171(10):5596-5600.
Medlin et al. (1988) Gene 71:491-499.
Gueho et al. (1989) System. Appl. Microbiol. 12:230-236.

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