Nucleic acid probes and methods

Details Nucleic acid probes and methods Nucleic acid probes and methods

1993-04-21

1997-02-25

Zitomer, Stephanie W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 267, C07H 2102, C07H 2104

Patent

active

056060459

ABSTRACT:
The present invention is directed to compositions comprising an oligonucleotide linked to a detectably labeled marker component comprising a fluorophore moiety which comprises a substantially planar, multidentate macrocyclic ligand coordinated to a central atom capable of coordinating with two axial ligands and two polyoxyhydrocarbyl moieties which are attached as axial ligands to the central atom. The present invention is also directed to nucleic acid hybridization and amplification methods employing such compositions.

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Hartmann et al., "Polymere mit dem Zentralatom eines Macrocyclus inder Hauptkette, 2: Polykondensations-reaktionen mith Germaniumkomplexen des Phthalocyanin und meso-Tetraphenyloporphins", Die Makromolekulare Chemie 176:831-847 (1975).
Hartmann et al., "Polymers with the Central Atom of a Macrocycle in the Main Chain 2; Poly Condensation Reactions with Germanium Complexes of Phthalocyanine and Meso-Tetra-Phenylporphin", Chemical Abstracts 83:79669 (1975).
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