Nucleic acid probe, test kit and diagnostic and purification met

Details Nucleic acid probe, test kit and diagnostic and purification met Nucleic acid probe, test kit and diagnostic and purification met

1992-03-06

1994-07-12

Parr, Margaret

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 5, 435 912, 536 243, 935 78, C12Q 168, C07H 2104

Patent

active

053288254

ABSTRACT:
An oligonucleotide is linked to a particle through a protein or carbohydrate to form a water-insoluble nucleic acid probe. The protein or carbohydrate has a pI of about 6 or less, and has been chemically modified with an acylating, alkylating or sulfonylating agent. The particle surface is substantially free of other proteins or carbohydrates. The probe is useful in various diagnostic and purification methods wherein hybridization of the oligonucleotide with a target nucleic acid is possible. In one instance, the probe can be used to capture a DNA strand which has been amplified using polymerase chain reaction techniques.

REFERENCES:
patent: 4591571 (1986-05-01), Kuboyama et al.
patent: 4683195 (1987-07-01), Mullis
patent: 4713326 (1987-12-01), Dattagupta et al.
patent: 4775619 (1988-10-01), Urdea
patent: 4812414 (1989-03-01), Warren et al.
patent: 4828978 (1989-05-01), Warren

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