Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1989-02-02
1992-04-28
Wax, Robert A.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
435 6, 435 91, 436501, 935 16, 935 78, 935 86, 935 88, C07H 2100, C12Q 168
Patent
active
051091240
ABSTRACT:
A polynucleotide probe with a label bearing a plurality of signalling moieties. The label is attached to the probe by the reaction of an amino and sulfhydryl reactive hetero bifunctional reagent with the probe and label, the reaction resulting in the oxidation of a sulfhydryl group of the label. The label may be attached to the 5' terminus of the probe, or to modified bases of the probe. Probes constructed according to the invention are useful in detecting target sequences in genomic DNA.
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Cate Richard L.
Ramachandran Kuzhalmannam L.
Biogen Inc.
Haley, Jr. James F.
Marschel Ardin H.
Wax Robert A.
Yankwich Leon R.
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