Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-01-14
2000-02-15
Martinelli, James
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
536 231, 536 235, C12Q 168
Patent
active
060251271
ABSTRACT:
Methods are provided for detection of target neoplastic nucleic acids in a tissue specimen, including a tumor margin or lymph node, and reagents therefor, wherein the nucleic acids are preferably mutant tumor suppressor genes or proto oncogenes. Methods for treatment of cell proliferative diseases utilizing ribozymes or antisense oligonucleotides specific for the target mutant nucleic acids and/or replacement wild type genes are also disclosed.
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Haile Lisa A.
Martinelli James
The Johns Hopkins University School of Medicine
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