Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-12-01
2009-06-16
Navarro, Mark (Department: 1645)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S235100, C435S252300, C435S320100
Reexamination Certificate
active
07547773
ABSTRACT:
The invention is a prostate specific antigen oligo-epitope peptide which comprises more than one PSA epitope peptide, which conforms to one or more human HLA class I motifs. The prostate specific antigen oligo-epitope peptide in combination with various HLA-class I molecules or interactions with various T-cell receptors elicits PSA specific cellular immune responses. The prostate specific antigen oligo-epitope peptide is useful as an immunogen in the prevention or treatment of prostatic cancer, in the inhibition of prostatic cancer cells and in the establishment and characterization of PSA-specific cytotoxic T-cell lines.
REFERENCES:
patent: 5565548 (1996-10-01), Neurath et al.
patent: 5840494 (1998-11-01), Katz et al.
patent: 5925362 (1999-07-01), Spitler et al.
patent: 6946133 (2005-09-01), Schlom et al.
patent: 91/02805 (1991-03-01), None
patent: 94/03205 (1994-02-01), None
patent: 9420127 (1994-09-01), None
patent: 95/04548 (1995-02-01), None
patent: 9528498 (1995-10-01), None
patent: 95/28958 (1995-11-01), None
Ezzell (J. NIH Res, vol. 7, pp. 46-49, 1995).
Spitler (Cancer Biotherapy vol. 10, pp. 1-3, 1995).
Boon (Adv. Can. Res. vol. 58, pp. 177-210, 1992).
Small (J. of Clin. Oncology vol. 22, No. 13, pp. 2515-2516, 2004).
Luzak et al., Molecular & Cellular Biology, Mar. 1988, pp. 1247-1252, vol. 8, No. 3.
Burgess et al., J. of Cell Biology, Nov. 1990, pp. 2129-2138, vol. III.
Wathen et al., J. Gen. Virol., 1989, pp. 2625-2635, vol. 70.
Lundwall et al., Molecular cloning of human prostate specific antigen cDNA, FEBS Letters, vol. 214, No. 2, pp. 317-322, Apr. 1987.
Gauthier et al., Characterization of rhesus monkey prostate specific antigen cDNA, Biochimica et Biophysica Acta, 1174, pp. 207-210, 1993.
Chapdelaine et al., “Southern Blot Analysis with Synthetic Oligonucleotides, Application to Prostate Protein Genes”, Int. J. Biochem., vol. 22, No. 1, pp. 75-82, 1990.
Karr et al, “Expression of Human Prostate Specific Antigen in a Transfected Murine Adenocarcinoma Cell Line: Development in a Murine Tumor Model for Immunotherapy of Prostate Cancer”, Journal of Cellular Biochemistry Supplement, 18D, Feb. 26-Apr. 17, 1994, 253, (Abstract Y511).
Karr et al., “The Presence of Prostate-specific Antigen-related Genes in Primates and the Expression of Recombinant Human Prostate-specific Antigen in a Transfected Murine Cell Line”, Cancer Research, vol. 55, No. 11, pp. 2455-2462, Jun. 1, 1995.
Bei et al., “A Recombinant Prostate Specific Antigen (PSA) Produced in a Baculovirus Expression Ssytem”, Proceedings of the Amer. Association for Cancer Res. Annual Meetnig, 36 Mar. 1995, p. 664 (Abs. 3833).
Bei et al., “Generation, Purification and Characterization of a Recombinant Source of Human Prostate-Specific Antigen”, Journal of Clinical Laboratory Analysis, 9:261-268, 1995.
Donovan, Jr., et al., “Immunotherapy of Prostate Cancer”, Problems in Urology, vol. 4, No. 3, pp. 489-505, Sep. 1990.
Abulafia et al., “In Vitro Production of T Cells Immunoreactive Against Prostate Specific Antigen: A Novel Approach for an Antigen-Specific Adoptive Immunotherapy Program for Prostate Cancer”, Joint Meetings of the American Association for Biochemistry and Molecular Biology, FASEB J., New Orleans, Louisiana, Jun. 4-7, 1990, vol. 4(7) (Abstract 1896).
Berzofsky et al., “Immunogenicity and Antigen Structure”, Fundamental Immunology, 2ndEd., W.E. Paul (Ed); Raven Press Ltd., New York, 1989, pp. 169-208.
Ross et al., “Adoptive Immunotherapy of Hormone-Refractory, Stage D2 Prostate Cancer using Ex Vivo Activated Autologous T Cells (Autolymphocyte Therapy): Results from a Pilot Study”, Biotechnology Therapeutics, 4(3&4), 197-211 (1993).
Sanda et al., “Demonstration of a Rational Strategy for Human Prostate Cancer Gene Therapy”, The Journal of Urology, vol. 151, 622-628, Mar. 1994.
Vieweg et al., “Immunotherapy of Prostate Cancer in the Dunning Rat Model: Use of Cytokine Gene Modified Tumor Vaccines”, Cancer Research, 54:7, p. 1760-1765, Apr. 1994.
Vieweg et al., “Efficient Gene Transfer with Adeno-associated Virus-based Plasmids Complexed to Cationic Liposomes for Gene Therapy of Human Prostate Cancer”, Cancer Research, vol. 55:11, pp. 2366-2372 Jun. 1995.
Hodge et al., A Recombinant Vaccina Virus Expressing Human Prostate-Specific Antigen (PSA): Safety and Immunogenicity in a non-Human Primate, Int. J. Cancer, 63, pp. 231-237 Oct. 9, 1995.
Akdas et al., “Human Leukocyte Antigen Subtype Analysis in Patients with Advanced Adenocarcinoma of the Prostate”, The Prostate, 23:111-113 Mar. 1994.
Sanda et al., “Molecular Characterization of Defective Antigen Processing in Human Prostate Cancer”, J. Nat'l Cancer Institute, vol. 87:4, pp. 280-285, Feb. 1995.
Sharpe et al., “Modulated expression of human leucocyte antigen class I and class II determinants in hyperplastic and malignant human epithelium”, British Journal of Urology, Nov. 1994, 74, 609-616.
Walsh et al., “Molecular Characterization of Heterogeneity in Immune Evasion by Human Prostate Cancer Cells: Implications for Prostate Cancer Gene Therapy”, The Journal of Urology, vol. 151, No. 5, May 1994 (Abstract 106).
Blades et al, “Loss of HLA Class I Expression in Prostate Cancer: Implications for Immunotherapy”, Urology, vol. 46:5, p. 686-687, Nov. 1995.
Schlom Jeffrey
Tsang Kwong-yok
Zaremba Sam
Leydig , Voit & Mayer, Ltd.
Navarro Mark
The United States of America as represented by the Department of
LandOfFree
Nucleic acid molecules encoding prostate specific antigen... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid molecules encoding prostate specific antigen..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecules encoding prostate specific antigen... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4079454