Nucleic acid molecules encoding PP32: a newly identified CD45-as

Details Nucleic acid molecules encoding PP32: a newly identified CD45-as Nucleic acid molecules encoding PP32: a newly identified CD45-as

1996-04-22

1998-12-08

Wax, Robert A.

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

4352523, 4353201, 435366, 536 235, C12N 500, C12N 120, C12N 1500, C07H 2104

Patent

active

058468226

ABSTRACT:
This invention relates to a newly identified protein useful for treating diseases of the immune system, methods for obtaining said protein, isolated nucleic acids encoding said protein, and methods for obtaining inhibitors of said protein. The protein of this invention is characterized by an apparent molecular weight of about 32 kD, an isoelectric point of about 4.0-4.5 and coprecipitation with CD45. The protein may also be used in in vitro or in vivo assays to identify inhibitors of T cell activation.

REFERENCES:
Altin, J.B. et al. (1994) "Evidence for an Association of CD45 with 32000-33000 MW Phosphoprotein of Murine T and B Lymphocytes", Immunology vol. 83, pp. 420-429.
Brown et al. (1994) "Multiple Components of the B Cell Antigen Receptor Complex Associate with the Protein Tyrosine Kinase Phosphatase, CD45", J. Biol. Chem., vol. 269, No. 25, pp. 17238-17244.
Schraven, B. et al. (1994) "LPAP, a Novel 32-kDa Phosphoprotein that Interacts with CD45 in Human Lymphocytes", J. Biol. Chem., vol. 269, No. 46, pp. 29102-29111.
Takeda et al. (1994), "Molecular Cloning of the CD45-associated 30-kDa Protein", The Journal of Biological Chemistry, vol. 269, No. 4, pp. 2357-2360.
Gyuris et al. (1993), "Cdi1, a Human G1 and S Phase Protein Phosphatase That Associates with Cdk2", Cell, vol. 75, pp. 791-803.
Schraven, B. et al. (1992) "Four CD45/P56lck-associated Phosphoproteins (pp. 29-pp. 32) Undergo Alterations in Human T Cell Activation", Eur. J. Immunol., vol. 22, No. 7, pp. 1857-1863.
Schraven, B. et al., (1992) "Four CD45/P56lck-associated Phosphoproteins (pp. 29-pp. 32) Undergo Alterations in Human T Cell Activation", Chemical Abstracts, vol. 117, No. 15, Abstract No. 149228.
Tonks et al. (1990), "CD45, an Integral Membrane Protein Tyrosine Phosphatase", The Journal of Biological Chemistry, vol. 265, No. 18, pp. 10674-10680.
Schraven et al., (1989), "Triggering of the alternative pathway of human T cell activation involves members of the T 200 family of glycoproteins", European Journal of Immunology, vol. 19, pp. 397-403.
Keiner et al. (1989) CD45-Protein Tyrosine Phosphatase Cross-Linking Inhibits T Cell Receptor CD3-Mediated Activation in Human T Cells. J. Immunol. 143(1):23-28.

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