Nucleic acid molecules encoding NRC interacting factor-1...

Details Nucleic acid molecules encoding NRC interacting factor-1... Nucleic acid molecules encoding NRC interacting factor-1...

2007-12-25

2007-12-25

Qian, Celine (Department: 1636)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S254110, C435S320100, C435S325000, C536S023100, C536S023500

Reexamination Certificate

active

10645250

ABSTRACT:
The present invention relates to isolated human and rat nucleic acid molecules encoding a protein or polypeptide that modulates transcriptional activation in a cell with or without collaboration with a nuclear hormone receptor transcriptional co-activator. The present invention also relates to the proteins or polypeptides encoded by those nucleic acid molecules, and antibodies against such proteins or polypeptides. The present invention also relates to a variety of uses for the nucleic acid molecules, proteins or polypeptides, and the related antibodies of the present invention, including methods of: regulating cellular proliferation, differentiation, and development; modulating the activity of a transcriptional co-activator complex and a transcription factor in cells; regulating hormone receptor activity and endocrine function in cells; and treating diabetes and insulin resistance in a subject.

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