Nucleic acid molecules encoding kappa.sub.3 opioid receptors, re

Details Nucleic acid molecules encoding kappa.sub.3 opioid receptors, re Nucleic acid molecules encoding kappa.sub.3 opioid receptors, re

1993-11-05

1998-05-05

Teng, Sally

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525233, 43525411, 435325, 435365, 536 235, C12N 1509

Patent

active

057472793

ABSTRACT:
The subject invention provides recombinant nucleic acid molecule which encodes a kappa.sub.3 opioid receptor, and the receptor encoded thereby. The subject invention further provides related anti-sense oligonucleotide molecules. The subject invention further provides a related host vector system, and method for using same. The subject invention further provides polyclonal and monoclonal antibodies capable of specifically binding to kappa.sub.3 opioid receptor, methods for obtaining same, and methods of using same to detect the presence of, and quantitatively determine the amount of, kappa.sub.3 opioid receptor in a sample, image and quantitatively determine the amount of cell membrane-bound kappa.sub.3 opioid receptor present in a subject, determine a subject's potential sensitivity to a kappa.sub.3 opioid receptor-specific agent, determine the affinity of an agent for kappa.sub.3 opioid receptor, and identify agonists and antagonists of kappa.sub.3 opioid receptor.

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