Nucleic acid molecules encoding glutx and uses thereof

Details Nucleic acid molecules encoding glutx and uses thereof Nucleic acid molecules encoding glutx and uses thereof

1999-04-26

2000-10-24

Elliott, George C.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 4, 435 74, 530300, 530350, G01N 3353, C07K 500, C07K 1400

Patent

active

061365475

ABSTRACT:
The invention concerns the human gene encoding GLUTX, a glucose transporter. GLUTX nucleic acid and polypeptides, as well as molecules which increase or decrease expression or activity of GLUTX, are useful in the diagnosis and treatment of disorders associated with aberrant hexose transport.

REFERENCES:
Fukumoto et al., "Cloning and Characterization of the Major Insulin-responsive Glucose Transporter . . . " J. of Biol. Chem. 264:7776-7779, 1989.
Kayano et al., "Human Facilitative Glucose Transporters" J. of Biol. Chem. 265:13276-13282, 1990.
Keller et al., "Functional Expression of the Human HepG2 and Rat Adipocyte Glucose . . . " J. of Biol. Chem. 264:18884-18889, 1989.
Mueckler et al., "Sequence and Structure of a Human Glucose Transporter" Science 229:941-945, 1985.
Thorens, B., "Glucose transporters in the regulation of intestinal, renal, and liver glucose fluxes" Amer. J. of Physiol. 270:G541-G553, 1996.

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