Nucleic acid molecules encoding endostatin protein and...

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S04400A, C536S023400, C536S023500

Reexamination Certificate

active

07655458

ABSTRACT:
An inhibitor of endothelial cell proliferation, capable of inhibiting angiogenesis and causing tumor regression, that is approximately 20 kDa and corresponds to a C-terminal fragment of collagen type XVIII, and methods of treating angiogenesis-related disease.

REFERENCES:
patent: 4889806 (1989-12-01), Olson et al.
patent: 1 177 005 (1998-03-01), None
patent: 58036391 (1983-03-01), None
patent: WO91/02058 (1991-02-01), None
patent: WO 91/10424 (1991-07-01), None
patent: WO 93/16716 (1993-09-01), None
patent: WO 95/25543 (1995-09-01), None
patent: WO 95/29242 (1995-11-01), None
patent: WO 97 15666 (1997-05-01), None
Verma et al (Nature, 1997, vol. 389, pp. 239-242).
Eck et al (Gene-Based Therapy, In: The Pharmacological Basis of Therapeutics, Goodman and Gilman, Ed.s, 1996, pp. 77-101).
Orkin (“Report and Recommendation of the Panel to Assess the NIH Investment in Research on Gene Therapy”, NIH, 1995).
Burgess et al (Journal of Cell Biology, 1990, vol. 111, pp. 2129-2138).
Lazar et al. Molecular and Cellular Biology, 1988, vol. 8, pp. 1247-1252.
Old and Primrose (Principles of Gene Manipulation, 1989, p. v).
Rehn et al (Journal of Biological Chemistry, May 1994, vol. 269, pp. 13929-13935).
Campbell (Monoclonal Antibody Technology, 1984, pp. 1-32).
Ibragimova and Eade (Biophysical Journal, Oct. 1999, vol. 77, pp. 2191-2198).
Abe, N. et al., “Identification of a Novel Collagen Chain Represented by Extensive Interruptions in the Triple-Helical Region”,Biochem. and Biophy. Resch. Comm., vol. 196, No. 2, pp. 576-582 (1993).
Algire, G.H. et al., “Vascular reactions of normal and malignant tumors in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants”,J. Natl. Canc. Inst., vol. 6, pp. 73-85 (1945).
Angiolillo, A.I. et al., “Human interferon-inducible Protein 10 is a potent inhibitor of angiogenesis in vivo”,J. Exp. Med.,vol. 182, pp. 155-162 (1995).
Brem, H. et al., “Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas”,J. Neurosurg., vol. 74, pp. 441-446 (1991).
Brockway, W. J. et al., “Measurement of the Binding of Antifibrinolytic Amino Acids to Various Plasminogens”,Arch. Biochem. Biophys., vol. 151, pp. 194-199 (1972).
Browne, M.J. et al., “Expression of Recombinant Human Plasminogen and Aglycoplasminogen in HeLa Cells”,Fibrinolysis, vol. 5, pp. 257-260 (1991).
Cao, Y. et al., “gro-β, α -C-X-C- Chemokine, Is an Angiogenesis Inhibitor That Suppresses the Growth of Lewis Lung Carcinoma in Mice”,J. Esp. Med., vol. 182, pp. 2069-2077 (1995).
Chen, C. et al., “A Strategy to Discover Circulating Angiogenesis Inhibitors Generated by Human Tumors”,Canc Resch., vol. 55, pp. 4230-4233 (1995).
Clapp, C. et al., “The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis”,Endocrinology, vol. 133, pp. 1292-1299 (1993).
Cleary, S. Mulkerrin et al., “Purification and Characterization of Tissue Plasminogen Activator Kringle-2Domain Expressed inEscherichia coli”, Biochem., vol. 28, pp. 1884-1891 (1989).
Dameron, K.M. et al., “Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1”,Science, vol. 265, pp. 1582-1584(1994).
Folkman, J., “Tumor angiogenesis and tissue factor”,Nature Med. vol. 2, pp. 167-168 (1996).
Folkman, J., “What is the Evidence that Tumors are Angiogenesis Dependent?”,J. Natl Canc Inst., vol. 82, pp. 4-6 (1990).
Folkman, J., “Angiogenesis in cancer, vascular, rheumatoid and other disease”,Nature Medicine, vol. 1, No. 1, pp. 27-31 (1995).
Folkman, J., “Long-term culture of capillary endothelial cells”,Proc. Natl. Acad. Sci. USA76, pp. 5217-5221 (1979).
Folkman, J. et al., “Induction of angiogenesis during the transition from hyperplasia to neoplasia”,Nature, vol. 339, pp. 58-61 (1989).
Folkman, J. et al. ,“Tumor Behavior in Isolated Perfused Organs in Vitro Growth and Metastases of Biopsy Material in Rabbit Thyroid and Canine Intestinal Segment”,Annals of Surgery, vol. 164, No. 3, pp. 491-501 (1996).
Folkman, J. , “Angiogenesis and Its Inhibitors”,Important Advances in Oncology, J.B. Lippincott Company, pp. 42-62 (1985).
Folkman, J., “Tumor Angiogenesis Therapeutic Implications”,NE J. of Med., No. 18, pp. 1182-1186 (1971).
Gavrieli, Y. et al., “Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation”,J. CellBiol., vol. 119, pp. 493-501 (1992).
Gimbrone, M.A. et al., “Tumor Growth and Neovascularization An Experimental Model using the Rabbit Cornea”,J. Natl. Canc. Inst., vol. 52, No. 2 pp. 413-427 (1974).
Gimbrone, M.A. et al., “Tumor Dormancy in Vivo by Prevention of Neovascularization”,J. of Experi. Med., vol. 136, pp. 261-276 (1972).
Good, D.J. et al., “A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin”,Proc. Nat. Acad. Sci. USA, vol. 87, pp. 6624-6628 (1990).
Grant, D.S. et al., “Scatter factor induces blood vessel formation in vivo”,Proc. Natl. Acad. Sci. USA, vol. 99, pp. 1937-1941 (1993).
Grant, D.S. et al., “Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro”,Cell, vol. 58, pp. 933-943 (1989).
Gross, J.L. et al., “Modulation of Solid Tumor Growth in vivo by bFGF”,Proc. Amer. Assoc. Canc. Resh, vol. 31, p. 79 (1990).
Gross, J.L. et al., “Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.”,Proc. Natl. Acad. Sci. USA, vol. 80, pp. 2623-2627 (1983).
Gunzler, W.A. et al., “The Primary Structure of High Molecular Mass Urokinase from Human Urine”,Hoppe-Seyler's Z. Physiol. Chem., vol. 363, pp. 1155-1165 (1982).
Gupta, S.K. et al., “A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4”,Proc. Natl. Acad. Sci. USA, vol. 92, pp. 7779-7803 (1995).
Holmgren, L. et al., “Dormancy of micrometastases Balanced proliferation and apoptosis in the presence of angiogenesis suppression”,Nature Medicine, vol. 1, No. 2, pp. 149-153 (1995).
Homandberg, G.A. et al., “Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth”,Am. J. Path., vol. 120, pp. 327-332 (1985).
Hori, A. et al., “Suppression of Solid tumor Growth by Immunoneutralizing Monoclonal Antibody against Human Basic Fibroblast Growth Factor”,Canc. Resch., vol. 51, pp. 6180-6184 (1991).
Ingber, D. et al., “Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumor growth”,Nature, vol. 348, pp. 555-557 (1990).
Johansson, J. et al., “Surfactant Protein B: Disulfide Bridges, Structural Properties, and Kringle Similarities”,Biochem., vol. 30, pp. 6917-6921 (1991).
Kandel, J. et al., “Neovascularization is Associated with a Switch to the Export of bFGF in the Multistep Development of Fibrosarcoma”,Cell, vol. 66, pp. 1095-1104 (1991).
Kim, K. J. et al., “Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo”,Nature, vol. 362, pp. 841-844 (1993).
Kivirikko, S. et al., “Primary Structure of the α1 Chain of Human Type XV Collagen and Exon-Intron Organization in the 3′ Region of the Corresponding Gene”,J. Bio. Chem., vol. 269, No. 7, pp. 4773-4779 (1994).
Knighton, D. et al., “Avascular and Vascular Phases of Tumor Growth in the Chick Embryo”,Br. J. Cancer, vol. 35, pp. 347-356 (1977).
Lein, W. M. et al., “The blood supply of experimental liver metastases. II. A Microcirculatory study of the normal and tumor vessels of the liver

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acid molecules encoding endostatin protein and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid molecules encoding endostatin protein and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecules encoding endostatin protein and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4194998

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.