Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2007-07-31
2007-07-31
Swope, Sheridan (Department: 1652)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S212000, C435S069100, C435S069600, C435S069700, C435S070100, C435S071100, C435S183000, C435S216000
Reexamination Certificate
active
10631558
ABSTRACT:
The present invention provides polynucleotides encoding clot-specific streptokinase proteins possessing altered plasminogen characteristics, including enhanced fibrin selectivity. The kinetics of plasminogen activation by these proteins are distinct from those of natural streptokinase, in that there is a temporary delay or lag in the initial rate of catalytic conversion of plasminogen to plasmin. Also disclosed are processes for preparing the proteins.
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Kumar Rajesh
Nihalani Deepak
Rajagopal Kammara
Roy Chaiti
Sahni Girish
Council of Scientific and Industrial Research
Swope Sheridan
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