Nucleic acid molecules encoding AKAP18 delta, a splice...

Details Nucleic acid molecules encoding AKAP18 delta, a splice... Nucleic acid molecules encoding AKAP18 delta, a splice...

2011-01-04

2011-01-04

Swope, Sheridan (Department: 1652)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C435S320100, C435S252300

Reexamination Certificate

active

07863432

ABSTRACT:
The invention relates to polynucleotides which encode a protein kinase A anchor proteins (AKAP) and the use of such polynucleotides to generate AKAP polypeptides or fusion proteins containing AKAP proteins. The present invention also relates to methods of determining the interaction of AKAP proteins with regulatory subunits of protein kinase A and methods for identifying cell-permeable substances.

REFERENCES:
patent: WO 99/62933 (1999-12-01), None
patent: WO 02/38592 (2002-05-01), None
Trotter et al, Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms. J Cell Biol. Dec. 27, 1999;147(7):1481-92.
UniProt—8.4 database Accession No. AKA7G—HUMAN from Trotter et al, Alternative splicing regulates the subcellular localization of A-kinase anchoring protein 18 isoforms. J Cell Biol. Dec. 27, 1999;147(7):1481-92. Alignment with SEQ ID No. 1.
Whisstock et al, Prediction of protein function from protein sequence and structure. Q Rev Biophys. Aug. 2003;36(3):307-40. Review.
Galye et al, Identification of regions in interleukin-1 alpha important for activity. J Biol Chem. Oct. 15, 1993;268(29):22105-11.
Klussmann, et al.: “Role and Identification of Protein Kinase A Anchoring Proteins in Vasopressin Mediated Aquaporin-2 Translocation” Kidney International, vol. 60, 2001, pp. 446-449.
Trotter et al.: “Alternative Splicing Regulates the Subcellular Localization of A -Kinase Anchoring Protein 18 Isoforms” The Journal of Cell Biology, vol. 147, No. 7, Dec. 27, 1999.
Klussmann et al.: “Protein Klinase A Anchoring Proteins Are Required for Vasopression-Mediated Translocation of Aquaproin-2 into Cell Membranes of Renal Principal Cells” The Journal of Biological Chemistry, vol. 274, No. 18, Feb. 19, 1999.
Oliveria et al.: “Imaging Kinase-AKAP79-Phosphatase Scaffold Complexes at the Plasma Membrane in Living Cells Using Fret Microscopy” The Journal of Cell Biology, vol. 160, No. 1, Jan. 1, 2003, pp. 101-112.
Klussman et al. “An inhibitory role of Rho in vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.” Abstract Only.
Schneider et al. “Peptide design by artificial neural networks and computer-based evolutionary search.”Proc. Natl. Acad. Sci. USAvol. 95, pp. 12179-12184, Oct. 1998.
Hundsrucker et al. “High-affinity AKAP7d—protein kinase A interaction yields novel protein kinase A-anchoring disruptor peptides.”Biochem. J., 396, 297-306, 2006.
Mary Louise Ruehr et al., “Cyclic AMP-dependent Protein Kinase Binding to A-kinase Anchoring . . . Protein Fusion Proteins,” The Journal of Biological Chemistry, Nov. 12, 1999, vol. 274, No. 46, pp. 33092-33096.
Srinivasan Vijayaraghavan et al., “Protein Kinase A-anchoring Inhibitor Peptides Arrest Mammalian Sperm Motility”, The Journal of Biological Chemistry, Feb. 21, 1997, vol. 272, No. 8, pp. 4747-4752.

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