Nucleic acid molecules comprising the prostate specific antigen

Details Nucleic acid molecules comprising the prostate specific antigen Nucleic acid molecules comprising the prostate specific antigen

1995-09-01

1999-07-06

Guzo, David

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435325, 435366, 536 241, C12P 2100, C12N 1585, C12N 510, C07H 2104

Patent

active

059196521

ABSTRACT:
The present invention provides isolated or purified nucleic acid molecules comprising a prostate specific antigen (PSA) promoter alone or in combination with a cytomegalovirus (CMV) promoter.

REFERENCES:
patent: 5087572 (1992-02-01), Castellino et al.
patent: 5168062 (1992-12-01), Stinski
patent: 5648478 (1997-07-01), Henderson
Orkin et al., "Report and Recommendations of the Panel to Assess the NIH Investment in Research on Gene Therapy", Dec. 1995.
Klobeck et al., "Genomic sequence of human prostate specific antigen (PSA)," Nucleic Acids Research, vol. 17, No. 10, (1989) p. 3981.
P.H. Riegman et al., "The Promoter of the Prostate-Specific Antigen Contains a Functional Androgen Responsive Element", Mol. Endo. (1991) vol. 5, No. 12, pp. 1921-1929 (Exhibit 1).
H. Brady et al., "Specific Ablation of Human Immunodeficiency Virus Tat-Expressing Cells by Conditionally Toxic Retroviruses", Proc. Natl. Acad. Sci. USA (1994) vol. 91, pp. 365-369 (Exhibit 2).
D. Chan et al., "Prostate-Specific Antigen as a Marker for Prostatic Cancer: a Monoclonal and a Polyclonal Immunoassay Compared", Clin. Chem. (1987) vol. 33, No. 10, pp. 1916-1920 (Exhibit 3).
P. Murtha et al., "Characterization of an Androgen Response Element in the 5' Promoter Region of the Gene", Biochemistry (1993) vol. 32, No. 25, pp. 6459-6464 (Exhibit 4).
Z. Ram et al., "In Situ Retroviral-mediated Gene Transfer for the Treatment of Brain Tumors", Cancer Research (1993) Cancer Research, vol. 53, pp. 83-88 (Exhibit 5).
C. Lee et al., "Two-Dimensional Characterization of Prostatic Acid Phosphatase, Prostatic Specific Antigen and Prostate Binding Protein in Expressed Prostatic Fluid", The Prostate, 9:135-146, (1986) (Exhibit 6).
H. Hoogenboom, "Targeting of Tumor Necrosis Factor to Tumor Cells: Secretion by Myeloma Cells of a Genetically Engineered Antibody-tumor Necrosis Factor Hybrid Molecule", Biochimica et Biophysica Acta, vol. 1096, (1991) pp. 345-354 (Exhibit 7).
C. Fong et al., "Regulation of Prostatic Carcinoma Cell Proliferation and Secretory Activity by Extracellular Matrix and Stromal Secretions", The Prostate, 21:121-131 (1992) pp. 121-131 (Exhibit 8).
M. Izawa, "cDNA Cloning of Androgen-Stimulated mRNAs in Rat Seminal Vesicles: Partial Characterization of Newly isolated cDNA Clones, pSv-1 and pSv-2", Endocrinol. Japon. 37 (2), (1990) pp. 223-232 (Exhibit 9).
L. Venkatesh, "Selective Induction of Toxicity to Human Cells Expressing Human Immunodeficiency Virus Type 1 Tat by a Conditionally Cytotoxic Adenovirus Vector", Proc. Natl. Acad. Sci., vol. 87, pp. 8746-8750, (1990) (Exhibit 10).
R. Henttu et al. "Androgens Up-Regulate the Human Prostate-Specific Antigen Messenger Ribonucleic Acid (mRNA), but Down-Regulate the Prostatic Acid Phosphatase mRNA in the LNCaP Cell Line", Endocrinology, vol. 130, No. 2, (1992) pp. 766-771 (Exhibit 11).
N. Ghyselinck et al., "Structural Organization and Regulation of the Gene for the Androgen-Dependent Glutathione Peroxidase-Like Protein Specific to the Mouse Epididymis", Molecular Endocrinology, (1993), pp. 258-269 (Exhibit 12).
G. Watwon et al., "Progressive Induction of mRNA Synthesis for Androgen-responsive Genes in Mouse Kidney", Molecular and Cellular Endocrinology, 68 (1990), pp. 67-74 (Exhibit 13).
L. Celis et al., "Proteins Interacting with an Androgen-responsive Unit in the C3(1) Gene Intron", Molecular and Cellular Endocrinology, 94 (1993) pp. 165-172 (Exhibit 14).
P. Rennie, et al., "Characterization of Two Cis-Acting DNA Elements Involved in the Androgen Regulation of the Probasin Gene", Molecular Endocrinology, vol. 7, No. 1, (1993), pp. 23-36 (Exhibit 15).
T. Wang et al., "Preliminary Evaluation of Measurement of Serum Prostate-Specific Antigen Level in Detection of Prostate Cancer", Annals of Clinical and Laboratory Science, vol. 16, No. 6, (1986), pp. 461-466 (Exhibit 16).
N. Dawson, "Treatment of Progressive Metastatic Prostate Cancer", Oncology, vol. 7, No. 5, (1993), pp. 17-24 (Exhibit 17).
S. Pang et al., "High Levels of Unintegrated HIV-1 DNA in Brain Tissue of AIDS Dementia Patients", Nature, vol. 343, (1990), pp. 85-89 (Exhibit 18).
S. Kuriyama et al., "A Potential Approach for Gene Therapy Targeting Hepatoma Using a Liver-Specific Promoter on a Retroviral Vector", Cell Structure and Function, vol. 16, (1991) pp. 503-509 (Exhibit 19).
C. Young et al., "Hormonal Regulation of Prostate-specific Antigen Messenger RNA in Human Prostatic Adenocarcinoma Cell Line LNCaP", Cancer Research, vol. 51, (1991) pp. 3748-3752 (Exhibit 20).
W. Tilley et al., "Androgen Receptor Gene Expression in Human Prostate Carcinoma Cell Lines", Cancer Research, vol. 50, (1990) pp. 5382-5386 (Exhibit 21).
C. Huggins et al., "I. The Effect of Castration, of Estrogen and of Androgen Injection on Serum Phosphatases in Metastatic Carcinoma of the Prostate", Studies on Prostatic Cancer, (1941), pp. 293-297 (Exhibit 22).
R. Vile et al., "In Vitro and in Vivo Targeting of Gene Expression to Melanoma Cells", Cancer Research, vol. 53, (1993), pp. 962-966 (Exhibit 23).
L. Emtage et al., "The Role of Prostate Specific Antigen in the Baseline Assessment of Patients Undergoing Hormone Therapy for Advanced Prostate Cancer", British Journal of Urology, (1987) 60:572-577 (Exhibit 24).

Affiliated with

Also associated with

Rating

Nucleic acid molecules comprising the prostate specific antigen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid molecules comprising the prostate specific antigen , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecules comprising the prostate specific antigen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-898398