Nucleic acid molecules coding for tumor suppressor proteins and

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

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4351723, 4352523, 435325, 435410, 4353201, 536 235, C12P 2100, C12N 1512

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058769722

ABSTRACT:
Described are novel proteins having the biological activity of a tumor suppressor protein and nucleic acid molecules coding for such proteins. Methods for the isolation of nucleic acid molecules encoding tumor suppressor proteins as well as nucleic acid molecules obtainable by said method are also provided. Further, vectors comprising said nucleic acid molecules wherein the nucleic acid molecules are operatively linked to regulatory elements allowing expression in prokaryotic or eukaryotic host cells can be used for the production of polypeptides encoded by said nucleic acid molecules which have tumor suppressor activity. Pharmaceutical and diagnostic compositions are provided comprising the nucleic acid molecules of the invention and/or comprising a nucleic acid molecule which is complementary to such a nucleic acid molecule. Described are also compositions which comprise polypeptides encoded by the described nucleic acid molecules which have tumor suppressor activity and/or an antibody specifically recognizing such polypeptides.

REFERENCES:
Spengler, D. et al., Nature (9 Sep. 1993) 365: 170-175.
Spengler, D. et al., 2nd International Symposium on VIP, PACAP, and Related eptides, Oct. 4-7, 1995.

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