Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-05-17
2005-05-17
Winkler, Ulrike (Department: 1648)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C424S232100, C435S320100, C536S023100
Reexamination Certificate
active
06894155
ABSTRACT:
The invention provides gp38 polypeptides, which play a role in immunomodulation, nucleic acid molecules encoding these polypeptides, and therapeutic and diagnostic methods employing these polypeptides and nucleic acid molecules. The invention also provides methods for identifying compounds that modulate the biological activities of gp38 nucleic acid molecules and polypeptides, and therapeutic methods employing these compounds.
REFERENCES:
patent: 5656465 (1997-08-01), Panicali et al.
patent: 5834419 (1998-11-01), McFadden et al.
patent: 6562376 (2003-05-01), Hooper et al.
patent: WO 9116431 (1991-10-01), None
patent: WO 9217583 (1992-10-01), None
patent: WO 9633730 (1996-10-01), None
patent: WO 9711714 (1997-04-01), None
patent: WO 9744054 (1997-11-01), None
Lee H-J. Studies of Yaba-like disease virus, a yatapoxvirus. Univeristy of Oxford, Thesis (Sep. 25, 2000) pp. 15-27 and 191-239.*
Vinyals et al. Failure of wild-type p53 gene therapy in human cancer cells expressing a mutant p53 protein. Gene Therapy (1999) vol. 6, pp. 22-33.*
Thompson L. Human gene therapy harsh lessons, high hopes. FDA Consumer Magazine (Sep.-Oct. 2000).*
Jackson et al. Expression of mouse interlukin-4 by a recombinant ectromelia virus suppress cytolytic lymphocyte responses and overcomes genetic resistance to mousepox. Journal of Virology (Feb. 2001) vol. 75, No. 3, pp. 1205-1210.*
Lee et al. The sequence of Yaba-like disease virus, a yatapoxvirus. 13th Symposium International sur les Poxvirus et Iridovirus, Sep. 2-6, 2000.*
Riffkin et al. A single amino-acid change between the antigenically differnt extracellular serine proteases V2 and B2 from Dichelobacter nodosus. Gene (1995) vol. 167, pp. 279-283.*
Gene Bank Sequence, AF153912.*
Gene Bank Sequence, AB015885.*
Gene Bank Sequence, D26580.*
Gene Bank Sequence, AJ293568.*
Ahuja et al., “Chemokine receptors and molecular mimicry,”Immunol. Today15:281 (1994).
Alcami et al., “Soluble Interferon-gamma receptors encoded by poxviruses,”Comp. Immunol. Microbiol. Infect. Dis.19:305 (1996).
Alcami et al., “Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity,”J. Virol.69:4633 (1995).
Alcami et al., “Receptors for gamma-interferon encoded by poxviruses: implications for the unknown origin of vaccinia virus,”Trends Microbiol.4:321 (1996).
Amano et al., “Identification and characterization of the thymidine kinase gene of Yaba virus,”J. of General Virology76:1109, (1995).
Barinaga, “Viruses launch their own Star Wars,”Science258:1730 (1992).
Chaudhuri et al., “Expression of the Duffy antigen in K562 cells,”J. Biol. Chem.269:7835 (1994).
Eisner et al., “Eotaxin-2 activates chemotaxis-related events and release of reactive oxygen species via pertussis toxin-sensitive G proteins in human eosinophils,”Eur. J. Immunol.28:2152 (1998).
Endres et al., “CD4-independent infection by HIV-1 is mediated by Fusin-CXCR4,”Cell87:745 (1996).
Essani et al., “Multiple anti-cytokine activities secreted from tanapox virus-infected cells,”Microbial. Pathogenesis17:347 (1994).
Fenger et al., “Proteins of Yaba monkey tumor virus I structural proteins,”J. of Virol.18:757, (1976).
Graham et al., “Myxoma virus M11L ORF encodes a protein for which cell surface localization is critical in manifestation of viral virulence,”Virol.191:112 (1992).
Graham et al., “The T1-35kDa family of poxvirus-secreted proteins bind chemokines and modulate leukocyte influx into virus-infected tissues,”Virol.229:12 (1997).
Hoffman et al., “Chemokine regulation of CNS T-cell infiltration in experimental autoimmune encephalomyelitis,”Research in Immunology149:790 (1998).
Horuk et al., “Molecular properties of the chemokine receptor family,”Tips15:159 (1994).
Hu et al., “Cowpox virus contains two copies of an early gene encoding a soluble secreted form of the type II TNF receptor,”Virol.204:343 (1994).
Knight et al., “Studies on tanapox virus,”Virol.172:116 (1989).
Kotwal et al., “Regulation of cytokine secretion by poxvirus encoded proteins,”Adv. In Exp. Med. and Biol.351:187, eds. Lindley, Westelck, and Kunkel, Plenum Press, NY (1992).
Lee et al, “The genome sequence of Yaba-like disease virus, a yatapoxvirus,”Virol.281:170 (2001).
Lomas et al., “Inhibition of plasmin, urokinase, tissue plasminogen activator, and C13by a myxoma virus serine proteinase inhibitor,”J. Biol. Chem.268:516 (1993).
Macen et al., “SERP1, a serine proteinase inhibitor encoded by myxoma virus, is a secreted glycoprotein that interferes with inflammation,”Virol.195:348 (1993).
McFadden, “Rabbit, hare, squirrel and swine poxviruses,”Encyclopedia of Virologypp. 1153-1160 (1997).
McFadden et al., “Myxoma T2 proteins as a model for poxvirus TNF receptor homologs,”J. of NeuroImmunology72:119 (1997).
McFadden et al., “Interruption of cytokine networks by poxviruses: lessons from myxoma virus,”J. Leukocyte Biol.57:731 (1995).
Mossman et al., “Myxoma virus M-T7, a secreted homolog of the interferon-gamma receptor, is a critical virulence factor for the development of myxomatosis in European rabbits,”Virol.215:17 (1996).
Mossman et al., “The myxoma virus-soluble interferon-gamma receptor homolog, M-T7, inhibits interferon-gamma in a species specific manner,”J. Biol. Chem.270:3031 (1995).
Mossman et al., “Species specificity of ectromella virus and vaccinia virus interferon-gamma binding proteins,” Virol. 208:762 (1995).
Mossman et al., “Interferon-γ receptors encoded by poxviruses,”Viroreceptors, Virokines And Related Immune Modulators Encoded by DNA Virusespp. 41-54 Ed: McFadden, R.G. Landers Co. (1994).
Neote et al., “Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor,”Cell72:415 (1993).
Neurath et al., “Search for Hepatitis B virus cell receptors reveals binding sites for interleukin 6 on the virus envelope protein,”J. Exp. Med.175:481 (1992).
Olsen et al., “Immunodiffusion analysis of Yaba poxvirus structural and associated antigens,”J. of Virol.5:212, (1970).
Opgenorth et al., “Deletion of the growth factor gene related to EGF and TFGα reduces virulence of malignant rabbit fibroma virus,”Virol.186:175 (1992).
Opgenorth et al., “Deletion analysis of two tandemly arranged virulence genes in myxoma virus, M11L and myxoma growth factor,”J. Virol.66:4720 (1992).
Opgenorth et al., “Transforming growth factor alpha, shope fibroma growth factor, and vaccinia growth factor can replace myxoma growth factor in the induction of myxomatosis in rabbits,”Virol.192:701 (1993).
Paulose et al., “Selective inhibition of TNF-α induced cell adhesion molecule gene expression by tanapox virus,”Microbial. Pathogenesis25:33 (1998).
Powell et al., “An I-kappa-B homolog encoded by African swine fever virus provides a novel mechanism for downregulation of proinflammatory cytokine responses in host macrophages,”J. Virol.70:8527 (1996).
Schrelber et al., “The myxoma virus TNF-receptor homologue (T2) inhibits tumor necrosis factor-alpha in a species-specific fashion,”Virol.204:692 (1994).
Sedger et al., “M-T2: A poxvirus TNF receptor homologue with dual activities,”Immunol. and Cell Biol.74:538 (1996).
Smith et al., “T2 open reading frame from the shope fibroma virus encodes a soluble form of the TNF receptor,”Biochem. Biophys. Res. Commun.176:335 (1991).
Smith, “Virus proteins that bind cytokines, chemokines or interferons,”Curr. Opin. Immunol.8:467 (1996).
Symons et al., “Vaccinia virus encodes a soluble type 1 interferon receptor of novel structure and broad species specificity,”C
Essani Karim
McFadden Grant
Bieker-Brady P.C. Kristina
Clark & Elbing LLP
Viron Therapeutics
Winkler Ulrike
LandOfFree
Nucleic acid molecules and polypeptides for immune modulation does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Nucleic acid molecules and polypeptides for immune modulation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecules and polypeptides for immune modulation will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3388064