Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1993-04-16
1996-08-27
Walsh, Stephen G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 231, 435 691, 4352401, 4352523, 43525411, 4353201, C12N 1509, C07H 2100, C07K 14705
Patent
active
055502210
ABSTRACT:
The present invention relates to an isolated nucleic acid fragment comprising a nucleic acid sequence coding for an amphotropic retrovirus receptor. This receptor is referred to as GLVR2 and has approximately 62% homology with the GLVR1 gene encoding Gibbon Ape Leukemia Virus (GALV) receptor. Differences in the type of retroviruses interacting with the receptors exist. The protein encoded by the GLVR2, cells transformed or transfected by the gene, and vectors containing the gene are also disclosed.
REFERENCES:
Sommerfelt, MA et al, Receptor Interference Groups of 20 Retroviruses Plating on Human Cells, Virology, vol. 176, No. 1, pp. 58-69, 1990.
Handelin, B. L., et al., Cell Surface Receptors for Murine Leukemia Viruses: Two Assays and Their Implications, Virology, vol. 140, No. 1, pp. 183-187 (1985).
Kawakami, T. G., et al., Antiagenic Studies on Gibbon Type-C Viruses, Transplantation Proceedings, vol. VI, No. 2 (Jun.), pp. 193-196, 1974.
Kawakami, T. G., et al., Letters to Nature, Nature New Biology, vol. 235, pp. 170-171, (1972).
Kawakami, T. G., et al., Onocogenicity of Gibbon Type-C Myelogenous Leukemia Virus, Int. J. Cancer: 25, 641-646 (1980).
Sanger, F., et al., DNA sequencing with chain-terminating inhibitors, Proc. Natl. Acad Sco, USA, vol. 74, No. 12, pp. 5463-5467, 1977.
O'Hara, B., et al., Characterization of a Human Gene Conferring Sensitivity to Infection by Gibbon Ape Leukemia Virus, Cell Growth & Differentiation, vol. 1: 119-127, 1990.
Kaelbling, M. et al., Localization of the Human Gene Allowing Infection by Gibbon Ape Leukemia Virus to Human Chromosome Region 2q11-q14 and to the Homologous Region on Mouse Chromosome 2, Journal of Virology, vol. 65, No. 4, pp. 1743-1747 (1991).
Garcia, J. V., et al., Localization of the Amphotropic Murine Leukemia Virus Receptor Gene to the Pericentromeric Region of Human Chromosome 8, Journal of Virology, vol. 65, No. 11, pp. 6316-6319, 1991.
MacLeod et al., Mol. Cell. Biol., vol. 10, p. 3663, 1990.
Johann Stephen V.
O'Hara Bryan M.
van Zeijl Marja
American Cyanamid Company
Lowney Karen A.
Robinson Joseph R.
Teng Sally P.
Walsh Stephen G.
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