Nucleic acid molecule encoding homer 2a protein

Details Nucleic acid molecule encoding homer 2a protein Nucleic acid molecule encoding homer 2a protein

2005-03-08

2005-03-08

Kemmener, Elizabeth (Department: 1647)

Chemistry: molecular biology and microbiology

Micro-organism, per se ; compositions thereof; proces of...

Bacteria or actinomycetales; media therefor

C435S254110, C435S325000, C435S320100, C536S023100, C536S023500

Reexamination Certificate

active

06864083

ABSTRACT:
A method is provided for identifying a compound that modulates a cellualr response associate with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.

REFERENCES:
Xiao et al. Genbank Accession No. AF093263, direct submission, Nov. 5, 1998.*
Shin et al. Homer 2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. J Cell Biol. 162(2):293-303, 2003.*
Xiao et al. Accession No. AF093262, direct submission, GenEmbl database, Nov. 5, 1998.*
Xiao et al. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21(4): 707-716, 1998.*
Tu et al. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21(4):717-26, 1998.*
Roche et al. Homer 1b regulates the trafficking of Group I metabotropic glutamate receptors. J Biol Chem 274(36):25953-25957, 1999.*
Nickels et al. Accession No. HSA17829. GenEmbl, direct submission. Jan. 7, 1999.*
Schoepp et al., “Pharmacological and functional characteristics of metabotropic excitatory amino acid receptors”,TIPS, Dec. 1990, vol. 11, pp. 508-515.
Brakeman et al., “Homer: a protein that selectively binds metabotropic glutamate receptors”,Nature, Mar. 20, 1997, vol. 386, pp. 284-288.
Ponting et al., “Identification of homer as a homologue of the Wiskott-Aldrich Syndrome protein suggests a receptor-binding function for WH1 domains,”J. Mol. Med., Nov.-Dec. 1997, vol. 75, pp. 769-771.
Abe et al., “Molecular characterization of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+ signal transduction”,J. Biol. Chem., Jul. 5, 1992, vol. 267, No. 9, pp. 13361-13368.
Nagase et al., “Prediction of the coding sequences of unidentified human genes. VII. The complete sequence of 100 new cDNA clones from brain which can code for large proteins in vitro.”DNA Res., 1997, vol. 4, No. 2, pp. 141-150.

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