Nucleic acid molecule encoding antigen associated with lyme dise

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 691, 4351723, 4353201, 4242341, 536 231, 536 237, C12P 2106, C07H 2102, C07H 2104, A61K 3902

Patent

active

056862679

ABSTRACT:
A vaccine against Lyme disease, wherein it contains one or more monoclonal antibodies which are specific for the 31 kD antigen (OspA) or the 34 kD antigen (OspB) of Borrelia burgdorferi. The present invention also provides a process for obtaining this vaccine, as well as new monoclonal antibodies and antigens.

REFERENCES:
Bergstrom et al. Molecular Microbiology 3(4): 479-486, 1989 (Apr.).
Howe et al. Science 227: 645-646, 1985.
Wallich et al. Nucleic Acids Research 17(21): 8864, 1989 (Nov.).
Howe et al. Infection and Immunity 54(1): 207-212 1986.
Simon et al.,"A mouse model for Borrelia burgdorferi infection: approach to vaccine against Lyme disease", Immunology Today, vol. 12, No. 1 p. 11 (1991).
Schaible et al.. "Monoclonal antibodies specific for the outer surface protein A (OspA) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice", Proc. Natl. Acad. Sci. USA, vol. 87, pp. 3768-3772, May 1990.
Fikrig et al., "Protection of Mice Against the Lyme Disease Agent by Immunizing with Recombinant OspA", Science,p. 553, Oct. 1990.
Bergstrom et al., "Molecular Analysis of linear plasmid-encoded major surface proteins, OspA and OspB, of the Lyme Disease sporochaete Borrelia burgdorferi", Molecular Microbiology vol. 3, No. 4, pp. 479-486 (1989).
Lane et al., "Antigenic Characteristics of Borrelia burgdorferi isolated from Ixodid Ticks in California", J. Clinical Microbiology, pp. 2344-2349, Oct. 1989.
Wallich et al,. "Cloning and sequencing of the gene encoding the outer surface protein A (OspA of a European Borrelia burgdorferi isolate", Nucleic Acids Research, Nov. 1989.
Schaible et al., "Demonstration of Antigen-Specific T Cells and Histophatological Alterations in Mice Experimentally Inoculated with Borrelia burgdorferi", pp. 41-47, Jan. 1989.
Barbour et al., "Heterogeneity of Major Proteins in Lyme Disease Borrelia burgdorferi A Molecular Analysis of North American and European Isolates", J. Infectious Diseases, p. 478, Sep. 1985.
Schaible et al., "The Severe Combined Immunodeficency (scid) Mouse",J. Exp. Med., vol. 170, pp. 1427-1432 (Oct. 1989).
Johnson et al., "Experimental Infection of the Hamster with Borrelia burgdorferi", Annals of the New York Academy of Sciences, p. 258 (1987).
Howe et al., "Organization of Genes Encoding Two Outer Membrane Proteins in the Lyme Disease Agent Borrelia burgdorferi within a Single Transcription Unit", Infection and Immunity, p. 207, Oct. 1986.
Howe et al., "A Single Recombinant Plasmid Expressing Two Major Outer Surface Proteins of the Lyme Disease Spirochete", Science, vol. 227 p. 645, Feb. 1985.
Barbour et al., "Heterogeneity of Major Proteins in Lyme Disease Borrelia burgdorferi A Molecular Analysis if North American and European Isolates", J. Infectious Diseases, vol. 152, No. 3, p. 478 Sep. 1985.
Bergstrom et al. Molecular Microbiology 3(4): 479-486, 1989.
Howe et al. Science 227: 645-646, 1985.
Howe et al. Infection and Immunity 54(1): 207-212, 1986.
Milch et al. Journal of Infectious Diseases 160(2): 351-353, 1989 (Aug.).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Nucleic acid molecule encoding antigen associated with lyme dise does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Nucleic acid molecule encoding antigen associated with lyme dise, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Nucleic acid molecule encoding antigen associated with lyme dise will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1227948

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.