Chemistry: molecular biology and microbiology – Vector – per se
Reexamination Certificate
2003-02-13
2009-08-18
Ewoldt, G. R (Department: 1644)
Chemistry: molecular biology and microbiology
Vector, per se
C536S023100, C536S023500
Reexamination Certificate
active
07575916
ABSTRACT:
There is provided an MHC class I peptide epitope from 5T4 antigen. In particular, there is provided a peptide epitope of 5T4 which comprises one of the following: (i) the amino acid sequence shown as SEQ ID No. 2; (ii) the minimal epitope from the amino acid sequence shown as SEQ ID No. 3; (iii) the minimal epitope from the amino acid sequence shown as SEQ ID No. 4. (iv) the minimal epitope from the amino acid sequence shown as SEQ ID No. 5. (v) the minimal epitope from the amino acid sequence shown as SEQ ID No. 6. (vi) the minimal epitope from the amino acid sequence shown as SEQ ID No. 7. There is also provided a vaccine comprising such a peptide (or precursor thereof) and its use to treat and/or prevent a disease, in particular a cancerous disease. There is also provided a nucleic acid molecule encoding a MHC class I peptide epitope from the human 5T4 tumor-associated antigen and vector comprising the nucleic acid molecule.
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Carroll Miles
Kingsman Susan
Redchenko Irina
Ewoldt G. R
Marianne DiBrino
Marshall & Gerstein & Borun LLP
Oxford Biomedica (UK) Limited
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