Nucleic acid molecule encoding a bifunctional protein, the prote

Details Nucleic acid molecule encoding a bifunctional protein, the prote Nucleic acid molecule encoding a bifunctional protein, the prote

1996-09-26

1999-08-03

Cunningham, Thomas M.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

8 to 10 amino acid residues in defined sequence

514 15, 435 71, 4241851, A61K 3804, G01N 3353

Patent

active

059326948

ABSTRACT:
The invention involves the identification of an isolated nucleic acid molecule which encodes a tumor rejection antigen. Various uses of this nucleic acid molecule and the protein it encodes are discussed.

REFERENCES:
Rammensee et al. Immunogenetics 41: 178, 1995.
Schonbach et al. J. Immunol. 154: 5951, 1995.
Fernandes-Alnemri et al., "In vitro activation of CPP32 and Mch3-by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains", Proc. Natl Acad. Sci. USA 93: 7464-7469 (Jul. 1996).
Fraser et al., "A License to Kill", Cell 85: 781-784 (Jun. 14, 1996).
Boldin et al., "Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1-amd TNF Receptor-Induced Cell Death", Cell 85: 803-815 (Jun. 14, 1996).
Muzio et al., "FLICE, A Novel FADD-Homologus ICE/CED-3-like Protease, Is Recruited to the CD95 (FasAPO-1) Death-Inducing signaling Complex", Cell 85: 817-827 (Jun. 14, 1996).

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