Nucleic acid molecule comprising a nucleic acid sequence...

Details Nucleic acid molecule comprising a nucleic acid sequence... Nucleic acid molecule comprising a nucleic acid sequence...

2006-10-24

2006-10-24

Wax, Robert A. (Department: 1653)

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

C530S350000, C530S855000

Reexamination Certificate

active

07125556

ABSTRACT:
A nucleic acid molecule or construct alone or with a promoter suitable for expression control is contemplated that codes for a haemocyanin, a haemocyanin domain or a fragment thereof with the immunological properties of at least one domain of haemocyanin, and comprises at least one intron sequence, as well as haemocyanin fusion proteins. The construct furthermore can comprise a nucleic acid sequence that codes for an antigen. Host cells are also contemplated that contain the nucleic acid molecule or construct and a recombinant expression product thereof. The invention furthermore relates to a pharmaceutical composition that comprises the expression product and antibodies obtainable by immunization of an animal therewith, as well as the use the antibodies in screening methods for the identification of tumors.

REFERENCES:
patent: 5021560 (1991-06-01), Montreuil et al.
patent: 5831033 (1998-11-01), Zetter et al.
patent: 5888775 (1999-03-01), Tai et al.
patent: 0 244 295 (1987-11-01), None
patent: 0 621 039 (1994-10-01), None
patent: WO 94/11019 (1994-05-01), None
patent: WO 00/55192 (2000-09-01), None
Keller et al., European Journal of Biochemistry, 1999, 264, 27-38.
Lieb et al., “Structures of two molluscan hemocyanin genes: Significance for gene evolution”,PNAS98(8):4546-4551 (Apr. 2001).
Drexel et al., “Complete Amino-Acid Sequence of a Functional Unit from a Molluscan Hemocyanin (Helix pomatia)”,Biol. Chem. Hoppe-Seyler386:617-635 (Jun. 1987).
J. V. Hamilton, et al., “Periodate-Sensitive Immunological Cross-Reactivity Between Keyhole Limpet Haemocyanin (KLH) and SerodiagnosticSchistosoma mansoniEgg Antigens,”Parasitology, 118:83-89 (Jan. 1, 1999).
Karen I. Miller, et al., “Sequence of theOctopus dofleiniHemocyanin Subunit: Structural and Evolutionary Implications,”J. Mol. Biol.278: 827-842 (May 15, 1998).
Stanka Stoeva, et al., “Primary Structure and Unusual Carbohydrate Moiety of Functional Unit 2-cof Keyhole Limpet Hemocyanin (KLH),”Bioclinica et Biophysica Acta., 1435: 94-109 (Nov. 16, 1999).
Wolfgang Gebauer, et al., Keyhole Limpet Hemocyanin Type 2 (KLH2): Detection and Immunolocalization of a Labile Functional Unith, Journal of Structural Biology128: 280-286 (Dec. 30, 1999).
J. Robin Harris, et al., “Immunoelectron Microscopy of Hemocyanin from the Keyhole Limpet (Megathura crenulata): A Parallel Subunit Model,”Journal of Structural Biology, 111: 96-104 (1993).
M. Rocia A. Carrera, et al., “Cocaine Vaccines: Antibody Protection Against Relapse in a Rat Model,”PNAS, 97(11) 6202-6206 (May 23, 2000).
Sabine M. Söhngen, et al., “Mass Determination, Subunit Organization and Control of Obligomerization States of Keyhole Limpet Hemocyanin (KLH),”Eur. J. Biochem., 248: 602-624 (1997).
M. Rocio A. Carrera, et al., “Suppression of Psychoactive Effects of Cocaine by Active Immunization,”NATURE, 378: 727-730 (Dec. 14, 1995).
Bernhard Lieb, et al., The Sequence of a Gastropod Hemocyanin (HtH1 fromHaliotis tuberculata),The Journal of Biological Chemistry, 275(8) 5675-5681 (Feb. 25, 2000).
Bernhard Lieb, et al., “Subunit Organization of the AbaloneHaliotis tuberculataHemocyanin Type 2 (HtH2), and the cDNA Sequence Encoding its Functional Units d, e, f, g and h,”Eur. J. Biochem.265: 134-144 (Oct. 1999).
Richard D. Swerdlow, et al., “Keyhole Limpet Hemocyanin: Structural and Functional Characterization of Two Different Subunits and Multimers,”Comp. Biochem. Physiol.,113B (3) 537-548 (1996).
Henning Keller, et al., “Abalone (Haliotis tuberculata) Hemocyanin Type 1 (HtH1) Organization of the ≈400 kDa Subunit, and Amino Acid Sequence of its Functional Units f, g and h,”Eur. J. Biochem.264: 27-39 (Aug. 1999).
J. Robin Harris, et al., “Keyhole Limpet Haemocyanin (KLH): Purification of Intact KLH1 Through Selective Dissociation of KLH2,”Micron, 26(3) 201-212 (1995).
Wolfgang Gebauer, et al., “Quaternary Structure, Subunits and Domain Patterns of Two Discrete Forms of Keyhole Limpet Hemocyanin: KLH1 and KLH2,”Zoology98: 51-68 (1994).
Geyer et al., “Identification and Characterization of Keyhole Limpet HemocyaninN-Glycans Mediating Cross-reactivity with Schistosoma mansoni”,J. of Biol. Chem., 280(49):40731-40748 (2005).
Kurokawa et al., “Hemocyanin from the keyhole dlimpetMegathura crenulata(KLH) carries a novel type of N-glycans with Gal(β1-6)Man-motifs”,Eur. J. Biochem, 269:5459-5473 (2002).

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