Nucleic acid molecule

Details Nucleic acid molecule Nucleic acid molecule

2007-03-06

2007-03-06

Qian, Celine (Department: 1636)

Chemistry: molecular biology and microbiology

Vector, per se

C536S023100

Reexamination Certificate

active

09728552

ABSTRACT:
The present invention is directed generally to an isolated nucleic acid molecule encompassing a neocentromere or a functional derivative thereof or a latent, synthetic or hybrid form thereof and its use inter alia in developing a range of eukaryotic artificial chromosomes including mammalian (e.g. human) and non-mammalian an artificial chromosomes. Such artificial chromosomes are useful in a range of genetic therapies.

REFERENCES:
patent: 5712134 (1998-01-01), Hadlaczky
patent: 5721118 (1998-02-01), Scheffler
patent: 6265211 (2001-07-01), Choo et al.
patent: WO 96/40965 (1996-12-01), None
patent: WO 98/08964 (1998-03-01), None
Abeliovich, D. et al., “dup(10q) Lacking α-satellite DNA in Bone Marrow Cells of a Patient With Acute Myeloid Leukemia”,Cancer Genet Cytogenet, 89:1-6 (1996).
Choo, K. H. Andy, “Chromatin Dynamics '97. Centromere DNA Dynamics: Latent Centromeres and Neocentromere Formation”,Am. J. Hum. Genet, 61:1225-1233 (1997).
Depinet, Theresa W., “Characterization of neo-centromeres in marker chromosomes lacking detectable alpha-satellite DNA”,Human Molecular Genetics, 6(8):1195-1204 (1997).
Du Sart, D., et al., (1997) “A functional neo-centromere formed through activation of a latent human centromere and consisting of non-alpha-satellite DNA”,Nature Genetics, 16:144-153.
Harrington J.J., et al., (1997) “Formation of de novo centromeres and construction of first-generation human artificial microchromosomes”,Nature Genetics, 15:345-355.
Ikeno, M., et al., (1998) “Construction of YAC-based mammalian artificial chromosomes”,Nature Biotechnology16:431-439.
Voullaire, L.E., et al., (1993) “A Functional Marker Centromerme with No Detectable Alpha-Satellite, Satellite III, or CENP-B Protein: Activation of a Latent Centromere?”,Am J. Hum. Genet 52:1153-1163.

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