Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1995-05-03
1998-05-12
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 912, 536 231, 536 254, 935 77, 935 78, C12Q 1934, C12Q 168, C07H 2102, C07H 2104
Patent
active
057503427
ABSTRACT:
This invention discloses high-affinity oligonucleotide ligands to complex tissue targets, specifically nucleic acid ligands having the ability to bind to complex tissue targets, and the methods for obtaining such ligands. Tissue targets comprise cells, subcellular components, aggregates or cells, collections of cells, and higher ordered structures. Specifically, nucleic acid ligands to peripheral blood mononuclear cells (PBMC), fibrin clots, and carotid arteries are described.
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Gold Larry
Schneider Dan
Speck Ulrich
Stephens Andrew
NeXstar Pharmaceuticals, Inc.
Schering Akiengesellschaft
Zitomer Stephanie W.
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