Nucleic acid hybridization and amplification method for detectio

Details Nucleic acid hybridization and amplification method for detectio Nucleic acid hybridization and amplification method for detectio

1993-07-06

1995-04-04

Fleisher, Mindy B.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 243, 435 912, C12Q 168, C07H 2104, C12P 1934

Patent

active

054037115

ABSTRACT:
A method of detection of nucleic acid (DNA or RNA) target sequence in which such a sequence serves as a cofactor for a catalytic reaction in which a complementary, labeled nucleic acid probe is cleaved such that the target sequence is released intact and can repeatedly recycle through the reaction pathway, thereby providing signal amplification.

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Bonner Methods in Enzymology 152 Academic Press New York, N.Y. pp. 55-61 (1986).
Sisodia et al Nuc Acids Res 15(5): 1995-2011 (1987).
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Maniatis et al Molec Cloning Cold Spring Harbor Press CSH N.Y. pp. 188-189, 230-233 1982.
Zoon Methods in Enzymology 152 Academic Press New York N.Y. pp. 25-29 1986.

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